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3059 items
MeasurementSet
IGVFDS9875NBZW
single-nucleus RNA sequencing assay (10x multiome with MULTI-seq)
Ansuman Satpathy, Stanford
Sample Summary
multiplexed sample: Homo sapiens (mixed sex) induced pluripotent stem differentiated cell specimen induced to islet of Langerhans for 11 days; Homo sapiens (mixed sex) induced pluripotent stem differentiated cell specimen induced to islet of Langerhans for 3 days; ... and 6 more samples
released
MeasurementSet
IGVFDS6464SOVZ
CRISPR base editing FACS screen integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide
Richard Sherwood, Brigham and Women's Hospital
Sample Summary
Homo sapiens (male) HepG2 cell line (sorting details: Sorted for Bottom 20% LDL-C uptake) modified with CRISPR base editing SpRY-ABE8e, transduced (lentivirus) with a guide library (MOI of 0.5)
released
MeasurementSet
IGVFDS5414UFNC
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (female, 83 years) substantia nigra tissue associated with Parkinson's disease, cerebral amyloid angiopathy, mild cognitive impairment; Homo sapiens (male, 78 years) posterior cingulate gyrus tissue associated with Parkinson's disease; ... and 10 more samples
multiplexed sample: Homo sapiens (male, 80 years) middle temporal gyrus tissue associated with Alzheimer disease, Parkinson's disease, cerebral amyloid angiopathy; Homo sapiens (male, 60 years) putamen tissue associated with Parkinson's disease; ... and 10 more samples
preview
MeasurementSet
IGVFDS2333QYKL
CRISPR base editing FACS screen integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide
Richard Sherwood, Brigham and Women's Hospital
Sample Summary
Homo sapiens (male) HepG2 cell line (sorting details: Sorted for Top 20% LDL-C uptake) modified with CRISPR base editing SpRY-ABE8e, transduced (lentivirus) with a guide library (MOI of 0.5)
released
MeasurementSet
IGVFDS3979YUTV
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (female, 82 years) substantia nigra tissue associated with cerebral amyloid angiopathy; Homo sapiens (female, 84 years) cerebellar cortex tissue associated with Parkinson's disease, mild cognitive impairment; ... and 10 more samples
CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-25% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library
preview
MeasurementSet
IGVFDS6647HVMC
CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (male) Jurkat cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library
released
MeasurementSet
IGVFDS3949LHHW
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (male, 79 years) posterior cingulate gyrus tissue; Homo sapiens (male, 80 years) posterior cingulate gyrus tissue associated with Parkinson's disease, cerebral amyloid angiopathy, mild cognitive impairment; ... and 8 more samples
preview
MeasurementSet
IGVFDS2606PSFA
CRISPR interference FlowFISH screen sorted on the expression of NFKBIA integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide associated with blood pressure
Guillaume Lettre, MHI
Sample Summary
Homo sapiens (female) TeloHAEC cell line (sorting details: FACS 60-80% expression of NFKBIA) modified with CRISPRi Sp-dCas9-KOX1-KRAB, transduced (lentivirus) with a guide library
released
MeasurementSet
IGVFDS4363PDBQ
CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-25% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library
released
MeasurementSet
IGVFDS2419JZMR
CRISPR interference FlowFISH screen sorted on the expression of TLNRD1 integrating a guide (sgRNA) library targeting candidate cis-regulatory elements in a genomic locus
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (female) TeloHAEC cell line (sorting details: FACS bin for 76-100% expression of TLNRD1) modified with CRISPRi Sp-dCas9-KOX1-KRAB, transfected with a guide library
released
MeasurementSet
IGVFDS4736IKQS
unsorted FACS input CRISPR prime editing Variant-EFFECTS integrating a guide (sgRNA) library targeting sequence variants in a genomic locus
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library
released
MeasurementSet
IGVFDS8153TZWE
10x multiome with scMito-seq
Leif Ludwig, MDC
Sample Summary
Homo sapiens (male, 29 years) peripheral blood mononuclear cell
preview
MeasurementSet
IGVFDS2414ATDI
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (male, 87 years) cerebellar cortex tissue associated with Parkinson's disease, cerebral amyloid angiopathy; Homo sapiens (male, 72 years) middle temporal gyrus tissue associated with Parkinson's disease; ... and 10 more samples
preview
MeasurementSet
IGVFDS3969UCCQ
CRISPR knockout RNA-seq integrating a guide (sgRNA) library targeting transcription start sites in GATA3
Charles Gersbach, Duke
Sample Summary
Homo sapiens CD8-positive, alpha-beta memory T cell modified with CRISPRko Sp-Cas9, transduced (lentivirus) with a guide library (MOI of 0.4)
released
MeasurementSet
IGVFDS4257XYUS
single-nucleus ATAC-seq (10x multiome)
Jimmie Ye, UCSF
Sample Summary
multiplexed sample: Homo sapiens (female, 27.0 years) peripheral blood mononuclear cell; Homo sapiens (female, 48.0 years) peripheral blood mononuclear cell; ... and 17 more samples
preview
MeasurementSet
IGVFDS3520MQEA
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (female, 83 years) putamen tissue associated with Parkinson's disease, cerebral amyloid angiopathy; Homo sapiens (male, 81 years) posterior cingulate gyrus tissue associated with Parkinson's disease, cerebral amyloid angiopathy; ... and 10 more samples
preview
MeasurementSet
IGVFDS5041NPBP
mixed CRISPR FlowFISH screen sorted on the expression of KITLG integrating a guide (sgRNA) library targeting accessible genome regions in many genomic loci
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (male) HCT116 cell line (sorting details: FACS bin F for 80-100% expression of KITLG) modified with CRISPRi Sp-dCas9-KOX1-KRAB, inactive AID system targeting RAD21, transfected with a guide library
released
MeasurementSet
IGVFDS3046IPKB
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (female, 78 years) putamen tissue associated with Parkinson's disease; Homo sapiens (male, 53 years) middle temporal gyrus tissue; ... and 10 more samples
preview
MeasurementSet
IGVFDS5264XYMB
single-nucleus ATAC-seq (10x multiome)
Ryan Corces, Gladstone Institute UCSF
Sample Summary
multiplexed sample: Homo sapiens (male, 70 years) substantia nigra tissue associated with Parkinson's disease; Homo sapiens (male, 80 years) posterior cingulate gyrus tissue; ... and 10 more samples
multiplexed sample: Homo sapiens (male, 70 years) substantia nigra tissue associated with Parkinson's disease; Homo sapiens (male, 80 years) posterior cingulate gyrus tissue; ... and 10 more samples
preview
MeasurementSet
IGVFDS5601DSMT
CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus
Jesse Engreitz, Stanford
Sample Summary
Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 26-50% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library