IGVFDS9875NBZW

single-nucleus RNA sequencing assay

/human-donors/IGVFDO2817PSCX/, /human-donors/IGVFDO2965ZTUG/, /human-donors/IGVFDO6169GISQ/, /human-donors/IGVFDO0720ONIQ/, /human-donors/IGVFDO4876ENMD/, /human-donors/IGVFDO4532PFAJ/, /human-donors/IGVFDO0324ZSAY/, /human-donors/IGVFDO8129FWUV/, /human-donors/IGVFDO1038DAII/, /human-donors/IGVFDO4001VEAC/, /human-donors/IGVFDO8315PGTI/, /human-donors/IGVFDO7670TOWV/, /human-donors/IGVFDO0183MFIP/, /human-donors/IGVFDO7813GMND/, /human-donors/IGVFDO7725MEWB/, /human-donors/IGVFDO9716HDYX/, /human-donors/IGVFDO7140TLQJ/, /human-donors/IGVFDO7650ICPB/, /human-donors/IGVFDO1221XJAX/, /human-donors/IGVFDO2492CCQG/, /human-donors/IGVFDO9904ZSML/, /human-donors/IGVFDO4452ZQSF/, /human-donors/IGVFDO8129UUAA/, /human-donors/IGVFDO8977PNMK/, /human-donors/IGVFDO3755LIBB/, /human-donors/IGVFDO7470LCGC/, /human-donors/IGVFDO9617JBWJ/, /human-donors/IGVFDO0657EMJH/, /human-donors/IGVFDO2650AGWB/, /human-donors/IGVFDO1364EAZP/, /human-donors/IGVFDO2750DZPB/, /human-donors/IGVFDO8893DMFF/, /human-donors/IGVFDO6162MIWK/, /human-donors/IGVFDO5261UCLF/, /human-donors/IGVFDO2620HPCX/, /human-donors/IGVFDO5656YCPC/, /human-donors/IGVFDO6441FSJH/, /human-donors/IGVFDO1964RNHE/, /human-donors/IGVFDO2379DTAU/, /human-donors/IGVFDO6638HIAD/, /human-donors/IGVFDO2718IDDQ/, /human-donors/IGVFDO4134ZWBU/, /human-donors/IGVFDO5614PTYQ/, /human-donors/IGVFDO5729MXSO/

experimental data

10x multiome with MULTI-seq

multiplexed sample: Homo sapiens (mixed sex) induced pluripotent stem differentiated cell specimen induced to islet of Langerhans for 11 days; Homo sapiens (mixed sex) induced pluripotent stem differentiated cell specimen induced to islet of Langerhans for 3 days; ... and 6 more samples

released

single-nucleus RNA sequencing assay (10x multiome with MULTI-seq)

fff841a3-91e6-4773-a75d-9eab106c3723

IGVFDS6464SOVZ

in vitro CRISPR screen using flow cytometry

experimental data

CRISPR FACS screen

Homo sapiens (male) HepG2 cell line (sorting details: Sorted for Bottom 20% LDL-C uptake) modified with CRISPR base editing SpRY-ABE8e, transduced (lentivirus) with a guide library (MOI of 0.5)

released

CRISPR base editing FACS screen integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide

ffe00f40-ac0d-4488-a686-3882394fe80d

IGVFDS5414UFNC

single-nucleus ATAC-seq

/human-donors/IGVFDO0909BNTN/, /human-donors/IGVFDO2045AFUW/, /human-donors/IGVFDO7754VJKM/, /human-donors/IGVFDO4108VCBA/, /human-donors/IGVFDO7095OCLJ/, /human-donors/IGVFDO3971UIZC/, /human-donors/IGVFDO8670MHXE/, /human-donors/IGVFDO4103FHPT/, /human-donors/IGVFDO2928PSUK/, /human-donors/IGVFDO4191KJBR/, /human-donors/IGVFDO4053HEKW/, /human-donors/IGVFDO5912PIZP/

experimental data

10x multiome

multiplexed sample: Homo sapiens (female, 83 years) substantia nigra tissue associated with Parkinson's disease, cerebral amyloid angiopathy, mild cognitive impairment; Homo sapiens (male, 78 years) posterior cingulate gyrus tissue associated with Parkinson's disease; ... and 10 more samples

preview

single-nucleus ATAC-seq (10x multiome)

ffdd4c54-4e93-4a82-b989-86ae6b5d0528

IGVFDS1331MCPD

in vitro CRISPR screen assay

experimental data

Proliferation CRISPR screen

Homo sapiens HUDEP-2 cell line modified with CRISPR cutting SpRY, transduced (lentivirus) with a guide library

released

Proliferation CRISPR cutting screen integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide

ff4d62e6-1ba9-4010-a061-d74377b15a06

IGVFDS4520GXBK

single-nucleus RNA sequencing assay

/human-donors/IGVFDO2031ESZX/, /human-donors/IGVFDO8891KXRJ/, /human-donors/IGVFDO9462VNBA/, /human-donors/IGVFDO3628ZBBZ/, /human-donors/IGVFDO2928PSUK/, /human-donors/IGVFDO0180JQCL/, /human-donors/IGVFDO1193ADXF/, /human-donors/IGVFDO5949WFOO/, /human-donors/IGVFDO7051PRHR/, /human-donors/IGVFDO4191KJBR/, /human-donors/IGVFDO6316TGCK/, /human-donors/IGVFDO7387JZDV/

experimental data

10x multiome

multiplexed sample: Homo sapiens (male, 80 years) middle temporal gyrus tissue associated with Alzheimer disease, Parkinson's disease, cerebral amyloid angiopathy; Homo sapiens (male, 60 years) putamen tissue associated with Parkinson's disease; ... and 10 more samples

preview

single-nucleus RNA sequencing assay (10x multiome)

ff27c3e6-a2bd-4e96-8eb5-a531fb73dde7

IGVFDS2333QYKL

in vitro CRISPR screen using flow cytometry

experimental data

CRISPR FACS screen

Homo sapiens (male) HepG2 cell line (sorting details: Sorted for Top 20% LDL-C uptake) modified with CRISPR base editing SpRY-ABE8e, transduced (lentivirus) with a guide library (MOI of 0.5)

released

CRISPR base editing FACS screen integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide

ff0b6255-6e09-4686-9119-0b6b88ab65d0

IGVFDS3979YUTV

single-nucleus ATAC-seq

/human-donors/IGVFDO4273OHGB/, /human-donors/IGVFDO6380POHE/, /human-donors/IGVFDO1193ADXF/, /human-donors/IGVFDO6837RJUQ/, /human-donors/IGVFDO6489DOPG/, /human-donors/IGVFDO2028IGVN/, /human-donors/IGVFDO7649CIGW/, /human-donors/IGVFDO4783EEYU/, /human-donors/IGVFDO8504RBEL/, /human-donors/IGVFDO8584FBOT/, /human-donors/IGVFDO1627RQLG/, /human-donors/IGVFDO0698ZMAQ/

experimental data

10x multiome

multiplexed sample: Homo sapiens (female, 82 years) substantia nigra tissue associated with cerebral amyloid angiopathy; Homo sapiens (female, 84 years) cerebellar cortex tissue associated with Parkinson's disease, mild cognitive impairment; ... and 10 more samples

preview

single-nucleus ATAC-seq (10x multiome)

fee07b3b-f2f5-48a6-9b86-4e018b84481b

IGVFDS3265EOGA

/human-donors/IGVFDO8129UUAA/, /human-donors/IGVFDO1221XJAX/, /human-donors/IGVFDO5729MXSO/, /human-donors/IGVFDO8893DMFF/, /human-donors/IGVFDO0720ONIQ/, /human-donors/IGVFDO4876ENMD/, /human-donors/IGVFDO2620HPCX/, /human-donors/IGVFDO9617JBWJ/, /human-donors/IGVFDO4134ZWBU/, /human-donors/IGVFDO2718IDDQ/, /human-donors/IGVFDO2750DZPB/, /human-donors/IGVFDO4001VEAC/, /human-donors/IGVFDO8977PNMK/, /human-donors/IGVFDO9904ZSML/, /human-donors/IGVFDO7650ICPB/, /human-donors/IGVFDO0183MFIP/, /human-donors/IGVFDO7813GMND/, /human-donors/IGVFDO0324ZSAY/, /human-donors/IGVFDO1038DAII/, /human-donors/IGVFDO8129FWUV/, /human-donors/IGVFDO9716HDYX/, /human-donors/IGVFDO2650AGWB/, /human-donors/IGVFDO2817PSCX/, /human-donors/IGVFDO5614PTYQ/, /human-donors/IGVFDO5656YCPC/, /human-donors/IGVFDO6441FSJH/, /human-donors/IGVFDO5261UCLF/, /human-donors/IGVFDO1964RNHE/, /human-donors/IGVFDO1364EAZP/, /human-donors/IGVFDO6638HIAD/, /human-donors/IGVFDO4532PFAJ/, /human-donors/IGVFDO2492CCQG/, /human-donors/IGVFDO7140TLQJ/, /human-donors/IGVFDO7670TOWV/, /human-donors/IGVFDO4452ZQSF/, /human-donors/IGVFDO2379DTAU/, /human-donors/IGVFDO7725MEWB/, /human-donors/IGVFDO7470LCGC/, /human-donors/IGVFDO8315PGTI/, /human-donors/IGVFDO2965ZTUG/, /human-donors/IGVFDO6169GISQ/, /human-donors/IGVFDO0657EMJH/, /human-donors/IGVFDO3755LIBB/, /human-donors/IGVFDO6162MIWK/

lipid-conjugated oligo sequencing

/measurement-sets/IGVFDS9875NBZW/, /measurement-sets/IGVFDS1125HXCL/

multiplexed sample: Homo sapiens (mixed sex) induced pluripotent stem differentiated cell specimen induced to islet of Langerhans for 11 days; Homo sapiens (mixed sex) induced pluripotent stem differentiated cell specimen induced to islet of Langerhans for 3 days; ... and 6 more samples

released

lipid-conjugated oligo sequencing for single-nucleus RNA sequencing assay (10x multiome with MULTI-seq), single-nucleus ATAC-seq (10x multiome with MULTI-seq)

fecb8d55-6ae5-4066-9983-07613d9e62f3

IGVFDS3032KHHX

single-cell ATAC-seq

experimental data

SHARE-seq

Mus musculus C57BL/6 (female) brain tissue (cellular sub pool: SS-PKR 130)

released

single-cell ATAC-seq (SHARE-seq)

fec43dfa-d933-4eac-b4cc-2f0a8b5c604d

IGVFDS2755YZNI

in vitro CRISPR screen using flow cytometry

experimental data

Variant-EFFECTS

Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-25% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library

preview

CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus

feb8e35f-3b97-49f7-b3c5-225c936360b6

IGVFDS6647HVMC

in vitro CRISPR screen using flow cytometry

experimental data

Variant-EFFECTS

Homo sapiens (male) Jurkat cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library

released

CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus

feb7d08a-1287-4cac-b362-f81fd5ba1f81

IGVFDS7903FOXV

/human-donors/IGVFDO7411YYYE/, /human-donors/IGVFDO1756PPKO/

intermediate analysis

multiplexed sample: Homo sapiens (female) H7-hESC differentiated cell specimen; Homo sapiens (male) GM25256 (WTC-11) differentiated cell specimen induced to cardiac muscle cell for 6 days; ... and 10 more samples

Homo sapiens multiplexed sample of GM25256 (WTC-11), H7-hESC

released

10x multiome with MULTI-seq: cell hashing barcodes, fragments, index, peaks, raw feature barcode matrix

feb0379c-6f89-409c-8579-b32a0aa29fb3

IGVFDS3949LHHW

single-nucleus ATAC-seq

/human-donors/IGVFDO2559GIIZ/, /human-donors/IGVFDO6380POHE/, /human-donors/IGVFDO7227BIXW/, /human-donors/IGVFDO6000JDZW/, /human-donors/IGVFDO7387JZDV/, /human-donors/IGVFDO9236YUAT/, /human-donors/IGVFDO0967LMSM/, /human-donors/IGVFDO4825ZGIS/, /human-donors/IGVFDO5205IAEO/, /human-donors/IGVFDO7186XJLL/

experimental data

10x multiome

multiplexed sample: Homo sapiens (male, 79 years) posterior cingulate gyrus tissue; Homo sapiens (male, 80 years) posterior cingulate gyrus tissue associated with Parkinson's disease, cerebral amyloid angiopathy, mild cognitive impairment; ... and 8 more samples

preview

single-nucleus ATAC-seq (10x multiome)

fe8a3ce7-9528-42c7-a190-0a2890bb9ad8

IGVFDS2606PSFA

in vitro CRISPR screen using flow cytometry

experimental data

CRISPR FlowFISH screen

Homo sapiens (female) TeloHAEC cell line (sorting details: FACS 60-80% expression of NFKBIA) modified with CRISPRi Sp-dCas9-KOX1-KRAB, transduced (lentivirus) with a guide library

released

CRISPR interference FlowFISH screen sorted on the expression of NFKBIA integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide associated with blood pressure

fe84d7f5-150b-45a5-aaed-9810416aa2e7

IGVFDS4363PDBQ

in vitro CRISPR screen using flow cytometry

experimental data

Variant-EFFECTS

Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-25% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library

released

CRISPR prime editing Variant-EFFECTS sorted on the expression of PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus

fe739718-a398-4e5c-b7b5-4d95497c90ad

IGVFDS2419JZMR

in vitro CRISPR screen using flow cytometry

experimental data

CRISPR FlowFISH screen

Homo sapiens (female) TeloHAEC cell line (sorting details: FACS bin for 76-100% expression of TLNRD1) modified with CRISPRi Sp-dCas9-KOX1-KRAB, transfected with a guide library

released

CRISPR interference FlowFISH screen sorted on the expression of TLNRD1 integrating a guide (sgRNA) library targeting candidate cis-regulatory elements in a genomic locus

fe738818-a459-4367-8223-af72aa6bca96

IGVFDS4736IKQS

in vitro CRISPR screen using flow cytometry

experimental data

Variant-EFFECTS

Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library

released

unsorted FACS input CRISPR prime editing Variant-EFFECTS integrating a guide (sgRNA) library targeting sequence variants in a genomic locus

fe6d143f-dbd2-40a5-b72b-55021f81951f

IGVFDS8153TZWE

single-cell RNA sequencing assay

experimental data

10x multiome with scMito-seq

Homo sapiens (male, 29 years) peripheral blood mononuclear cell

preview

10x multiome with scMito-seq

fe691699-aab9-4f5b-9441-94f41f4020b1

IGVFDS2414ATDI

single-nucleus ATAC-seq

/human-donors/IGVFDO7720JNYZ/, /human-donors/IGVFDO0411QFOF/, /human-donors/IGVFDO7606UOXI/, /human-donors/IGVFDO9028PIDF/, /human-donors/IGVFDO4191KJBR/, /human-donors/IGVFDO0966KXTA/, /human-donors/IGVFDO1052TZWO/, /human-donors/IGVFDO0773NPOH/, /human-donors/IGVFDO0967LMSM/, /human-donors/IGVFDO6837RJUQ/, /human-donors/IGVFDO6513APBX/, /human-donors/IGVFDO3500WGWY/

experimental data

10x multiome

multiplexed sample: Homo sapiens (male, 87 years) cerebellar cortex tissue associated with Parkinson's disease, cerebral amyloid angiopathy; Homo sapiens (male, 72 years) middle temporal gyrus tissue associated with Parkinson's disease; ... and 10 more samples

preview

single-nucleus ATAC-seq (10x multiome)

fe41d4f3-932f-4b0b-9a24-c80507121a08

IGVFDS3969UCCQ

bulk RNA-seq assay

experimental data

RNA-seq

Homo sapiens CD8-positive, alpha-beta memory T cell modified with CRISPRko Sp-Cas9, transduced (lentivirus) with a guide library (MOI of 0.4)

released

CRISPR knockout RNA-seq integrating a guide (sgRNA) library targeting transcription start sites in GATA3

fe29fcd6-36dd-4bba-acde-cc30fbb5ebc7

IGVFDS4257XYUS

single-nucleus ATAC-seq

/human-donors/IGVFDO5077XACB/, /human-donors/IGVFDO2354YSJQ/, /human-donors/IGVFDO2417TCIH/, /human-donors/IGVFDO6865EJIU/, /human-donors/IGVFDO4017UKOH/, /human-donors/IGVFDO2392CNUG/, /human-donors/IGVFDO9765ZYZB/, /human-donors/IGVFDO9142UFHT/, /human-donors/IGVFDO0981AWNH/, /human-donors/IGVFDO1259OYEU/, /human-donors/IGVFDO4022UBXD/, /human-donors/IGVFDO6823IRJG/, /human-donors/IGVFDO0611IZWA/, /human-donors/IGVFDO1684FBAQ/, /human-donors/IGVFDO6356VGZI/, /human-donors/IGVFDO0832MKLB/, /human-donors/IGVFDO8210ZYFU/, /human-donors/IGVFDO7888FEQZ/, /human-donors/IGVFDO6094ZBJQ/

experimental data

10x multiome

multiplexed sample: Homo sapiens (female, 27.0 years) peripheral blood mononuclear cell; Homo sapiens (female, 48.0 years) peripheral blood mononuclear cell; ... and 17 more samples

preview

single-nucleus ATAC-seq (10x multiome)

fe1f6325-4877-4a71-8933-bd9953c5129f

IGVFDS3520MQEA

single-nucleus ATAC-seq

/human-donors/IGVFDO0877AIRF/, /human-donors/IGVFDO2031ESZX/, /human-donors/IGVFDO4015EJFT/, /human-donors/IGVFDO7095OCLJ/, /human-donors/IGVFDO5410JIJT/, /human-donors/IGVFDO7720JNYZ/, /human-donors/IGVFDO2127ZJPS/, /human-donors/IGVFDO1997RFPJ/, /human-donors/IGVFDO3911JQLE/, /human-donors/IGVFDO4103FHPT/, /human-donors/IGVFDO8547HLIG/, /human-donors/IGVFDO6013FYCW/

experimental data

10x multiome

multiplexed sample: Homo sapiens (female, 83 years) putamen tissue associated with Parkinson's disease, cerebral amyloid angiopathy; Homo sapiens (male, 81 years) posterior cingulate gyrus tissue associated with Parkinson's disease, cerebral amyloid angiopathy; ... and 10 more samples

preview

single-nucleus ATAC-seq (10x multiome)

fe1c0684-20ed-4a0a-a2f0-04d4340c8983

IGVFDS5041NPBP

in vitro CRISPR screen using flow cytometry

experimental data

CRISPR FlowFISH screen

Homo sapiens (male) HCT116 cell line (sorting details: FACS bin F for 80-100% expression of KITLG) modified with CRISPRi Sp-dCas9-KOX1-KRAB, inactive AID system targeting RAD21, transfected with a guide library

released

mixed CRISPR FlowFISH screen sorted on the expression of KITLG integrating a guide (sgRNA) library targeting accessible genome regions in many genomic loci

fe1a8271-fd7e-454e-ae2c-187f1d46d77d

IGVFDS8473JDSO

quantification DNA barcode sequencing

Mus musculus WD44 (male) mouse embryonic stem differentiated cell specimen induced to embryoid body for 4 days transfected with a reporter library

released

quantification DNA barcode sequencing for MPRA integrating a reporter library targeting accessible genome regions in many genomic loci

fdfabd72-0a73-454b-bf93-f598df360118

IGVFDS3046IPKB

single-nucleus ATAC-seq

/human-donors/IGVFDO5228HTJC/, /human-donors/IGVFDO8458OKEW/, /human-donors/IGVFDO9247BEUS/, /human-donors/IGVFDO1997RFPJ/, /human-donors/IGVFDO2559GIIZ/, /human-donors/IGVFDO8891KXRJ/, /human-donors/IGVFDO5410JIJT/, /human-donors/IGVFDO8155MCUV/, /human-donors/IGVFDO2928PSUK/, /human-donors/IGVFDO0182KXUM/, /human-donors/IGVFDO7315DYIP/, /human-donors/IGVFDO4103FHPT/

experimental data

10x multiome

multiplexed sample: Homo sapiens (female, 78 years) putamen tissue associated with Parkinson's disease; Homo sapiens (male, 53 years) middle temporal gyrus tissue; ... and 10 more samples

preview

single-nucleus ATAC-seq (10x multiome)

fdc66444-0fda-492a-b8cc-013c441d21a3