IGVFFI4057VSBO

preview
validated
1{
2    "@context": "/terms/",
3    "@id": "/tabular-files/IGVFFI4057VSBO/",
4    "@type": [
5        "TabularFile",
6        "File",
7        "Item"
8    ],
9    "accession": "IGVFFI4057VSBO",
10    "aliases": [
11        "jesse-engreitz:PPIF_promoter_8mer_insertion_THP1_Variant-EFFECTS_File_Standardized"
12    ],
13    "assay_titles": [
14        "Variant-EFFECTS"
15    ],
16    "assembly": "GRCh38",
17    "audit": {},
18    "award": {
19        "@id": "/awards/HG011972/",
20        "component": "functional characterization"
21    },
22    "barcode_map_for": [],
23    "checkfiles_version": "v20",
24    "content_md5sum": "359e698f629cac4960305aa99749c63f",
25    "content_type": "variant effects",
26    "controlled_access": false,
27    "creation_timestamp": "2025-03-29T00:22:03.315488+00:00",
28    "derived_from": [
29        "/tabular-files/IGVFFI2325NRPY/"
30    ],
31    "derived_manually": true,
32    "description": "Manually standardized output of Variant-EFFECTS pipeline, formatted for GRCh38 with SPDI variant IDs",
33    "file_format": "tsv",
34    "file_format_specifications": [
35        {
36            "@id": "/documents/9d0ad6fb-777c-4cb6-a1c4-8ff7a41b17a1/",
37            "description": "This file type describes results from genome editing experiments that measure the effect of a variant on an endogenous gene in the genome."
38        }
39    ],
40    "file_set": {
41        "@id": "/analysis-sets/IGVFDS5056OAGR/",
42        "@type": [
43            "AnalysisSet",
44            "FileSet",
45            "Item"
46        ],
47        "accession": "IGVFDS5056OAGR",
48        "data_use_limitation_summaries": [
49            "no certificate"
50        ],
51        "file_set_type": "principal analysis",
52        "samples": [
53            {
54                "@id": "/in-vitro-systems/IGVFSM7602FHUT/",
55                "@type": [
56                    "InVitroSystem",
57                    "Biosample",
58                    "Sample",
59                    "Item"
60                ],
61                "accession": "IGVFSM7602FHUT",
62                "classifications": [
63                    "cell line"
64                ],
65                "modifications": [
66                    {
67                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
68                        "modality": "prime editing",
69                        "status": "released",
70                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
71                    }
72                ],
73                "sample_terms": [
74                    {
75                        "@id": "/sample-terms/EFO_0001253/",
76                        "status": "released",
77                        "term_name": "THP-1"
78                    }
79                ],
80                "status": "released",
81                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
82                "taxa": "Homo sapiens"
83            },
84            {
85                "@id": "/in-vitro-systems/IGVFSM8470FMQN/",
86                "@type": [
87                    "InVitroSystem",
88                    "Biosample",
89                    "Sample",
90                    "Item"
91                ],
92                "accession": "IGVFSM8470FMQN",
93                "classifications": [
94                    "cell line"
95                ],
96                "modifications": [
97                    {
98                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
99                        "modality": "prime editing",
100                        "status": "released",
101                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
102                    }
103                ],
104                "sample_terms": [
105                    {
106                        "@id": "/sample-terms/EFO_0001253/",
107                        "status": "released",
108                        "term_name": "THP-1"
109                    }
110                ],
111                "status": "released",
112                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
113                "taxa": "Homo sapiens"
114            },
115            {
116                "@id": "/in-vitro-systems/IGVFSM8224ZLFH/",
117                "@type": [
118                    "InVitroSystem",
119                    "Biosample",
120                    "Sample",
121                    "Item"
122                ],
123                "accession": "IGVFSM8224ZLFH",
124                "classifications": [
125                    "cell line"
126                ],
127                "modifications": [
128                    {
129                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
130                        "modality": "prime editing",
131                        "status": "released",
132                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
133                    }
134                ],
135                "sample_terms": [
136                    {
137                        "@id": "/sample-terms/EFO_0001253/",
138                        "status": "released",
139                        "term_name": "THP-1"
140                    }
141                ],
142                "status": "released",
143                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
144                "taxa": "Homo sapiens"
145            },
146            {
147                "@id": "/in-vitro-systems/IGVFSM0075VGTB/",
148                "@type": [
149                    "InVitroSystem",
150                    "Biosample",
151                    "Sample",
152                    "Item"
153                ],
154                "accession": "IGVFSM0075VGTB",
155                "classifications": [
156                    "cell line"
157                ],
158                "modifications": [
159                    {
160                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
161                        "modality": "prime editing",
162                        "status": "released",
163                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
164                    }
165                ],
166                "sample_terms": [
167                    {
168                        "@id": "/sample-terms/EFO_0001253/",
169                        "status": "released",
170                        "term_name": "THP-1"
171                    }
172                ],
173                "status": "released",
174                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
175                "taxa": "Homo sapiens"
176            },
177            {
178                "@id": "/in-vitro-systems/IGVFSM1683BAMH/",
179                "@type": [
180                    "InVitroSystem",
181                    "Biosample",
182                    "Sample",
183                    "Item"
184                ],
185                "accession": "IGVFSM1683BAMH",
186                "classifications": [
187                    "cell line"
188                ],
189                "modifications": [
190                    {
191                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
192                        "modality": "prime editing",
193                        "status": "released",
194                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
195                    }
196                ],
197                "sample_terms": [
198                    {
199                        "@id": "/sample-terms/EFO_0001253/",
200                        "status": "released",
201                        "term_name": "THP-1"
202                    }
203                ],
204                "status": "released",
205                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
206                "taxa": "Homo sapiens"
207            },
208            {
209                "@id": "/in-vitro-systems/IGVFSM0701VWIZ/",
210                "@type": [
211                    "InVitroSystem",
212                    "Biosample",
213                    "Sample",
214                    "Item"
215                ],
216                "accession": "IGVFSM0701VWIZ",
217                "classifications": [
218                    "cell line"
219                ],
220                "modifications": [
221                    {
222                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
223                        "modality": "prime editing",
224                        "status": "released",
225                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
226                    }
227                ],
228                "sample_terms": [
229                    {
230                        "@id": "/sample-terms/EFO_0001253/",
231                        "status": "released",
232                        "term_name": "THP-1"
233                    }
234                ],
235                "status": "released",
236                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
237                "taxa": "Homo sapiens"
238            },
239            {
240                "@id": "/in-vitro-systems/IGVFSM0863WEQJ/",
241                "@type": [
242                    "InVitroSystem",
243                    "Biosample",
244                    "Sample",
245                    "Item"
246                ],
247                "accession": "IGVFSM0863WEQJ",
248                "classifications": [
249                    "cell line"
250                ],
251                "modifications": [
252                    {
253                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
254                        "modality": "prime editing",
255                        "status": "released",
256                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
257                    }
258                ],
259                "sample_terms": [
260                    {
261                        "@id": "/sample-terms/EFO_0001253/",
262                        "status": "released",
263                        "term_name": "THP-1"
264                    }
265                ],
266                "status": "released",
267                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
268                "taxa": "Homo sapiens"
269            },
270            {
271                "@id": "/in-vitro-systems/IGVFSM9472SJJU/",
272                "@type": [
273                    "InVitroSystem",
274                    "Biosample",
275                    "Sample",
276                    "Item"
277                ],
278                "accession": "IGVFSM9472SJJU",
279                "classifications": [
280                    "cell line"
281                ],
282                "modifications": [
283                    {
284                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
285                        "modality": "prime editing",
286                        "status": "released",
287                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
288                    }
289                ],
290                "sample_terms": [
291                    {
292                        "@id": "/sample-terms/EFO_0001253/",
293                        "status": "released",
294                        "term_name": "THP-1"
295                    }
296                ],
297                "status": "released",
298                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
299                "taxa": "Homo sapiens"
300            },
301            {
302                "@id": "/in-vitro-systems/IGVFSM3254FGUG/",
303                "@type": [
304                    "InVitroSystem",
305                    "Biosample",
306                    "Sample",
307                    "Item"
308                ],
309                "accession": "IGVFSM3254FGUG",
310                "classifications": [
311                    "cell line"
312                ],
313                "modifications": [
314                    {
315                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
316                        "modality": "prime editing",
317                        "status": "released",
318                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
319                    }
320                ],
321                "sample_terms": [
322                    {
323                        "@id": "/sample-terms/EFO_0001253/",
324                        "status": "released",
325                        "term_name": "THP-1"
326                    }
327                ],
328                "status": "released",
329                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
330                "taxa": "Homo sapiens"
331            },
332            {
333                "@id": "/in-vitro-systems/IGVFSM3062EIHZ/",
334                "@type": [
335                    "InVitroSystem",
336                    "Biosample",
337                    "Sample",
338                    "Item"
339                ],
340                "accession": "IGVFSM3062EIHZ",
341                "classifications": [
342                    "cell line"
343                ],
344                "modifications": [
345                    {
346                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
347                        "modality": "prime editing",
348                        "status": "released",
349                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
350                    }
351                ],
352                "sample_terms": [
353                    {
354                        "@id": "/sample-terms/EFO_0001253/",
355                        "status": "released",
356                        "term_name": "THP-1"
357                    }
358                ],
359                "status": "released",
360                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
361                "taxa": "Homo sapiens"
362            },
363            {
364                "@id": "/in-vitro-systems/IGVFSM6375ITVK/",
365                "@type": [
366                    "InVitroSystem",
367                    "Biosample",
368                    "Sample",
369                    "Item"
370                ],
371                "accession": "IGVFSM6375ITVK",
372                "classifications": [
373                    "cell line"
374                ],
375                "modifications": [
376                    {
377                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
378                        "modality": "prime editing",
379                        "status": "released",
380                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
381                    }
382                ],
383                "sample_terms": [
384                    {
385                        "@id": "/sample-terms/EFO_0001253/",
386                        "status": "released",
387                        "term_name": "THP-1"
388                    }
389                ],
390                "status": "released",
391                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
392                "taxa": "Homo sapiens"
393            },
394            {
395                "@id": "/in-vitro-systems/IGVFSM7338BXZP/",
396                "@type": [
397                    "InVitroSystem",
398                    "Biosample",
399                    "Sample",
400                    "Item"
401                ],
402                "accession": "IGVFSM7338BXZP",
403                "classifications": [
404                    "cell line"
405                ],
406                "modifications": [
407                    {
408                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
409                        "modality": "prime editing",
410                        "status": "released",
411                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
412                    }
413                ],
414                "sample_terms": [
415                    {
416                        "@id": "/sample-terms/EFO_0001253/",
417                        "status": "released",
418                        "term_name": "THP-1"
419                    }
420                ],
421                "status": "released",
422                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
423                "taxa": "Homo sapiens"
424            },
425            {
426                "@id": "/in-vitro-systems/IGVFSM8972CLRU/",
427                "@type": [
428                    "InVitroSystem",
429                    "Biosample",
430                    "Sample",
431                    "Item"
432                ],
433                "accession": "IGVFSM8972CLRU",
434                "classifications": [
435                    "cell line"
436                ],
437                "modifications": [
438                    {
439                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
440                        "modality": "prime editing",
441                        "status": "released",
442                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
443                    }
444                ],
445                "sample_terms": [
446                    {
447                        "@id": "/sample-terms/EFO_0001253/",
448                        "status": "released",
449                        "term_name": "THP-1"
450                    }
451                ],
452                "status": "released",
453                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
454                "taxa": "Homo sapiens"
455            },
456            {
457                "@id": "/in-vitro-systems/IGVFSM0583RNTC/",
458                "@type": [
459                    "InVitroSystem",
460                    "Biosample",
461                    "Sample",
462                    "Item"
463                ],
464                "accession": "IGVFSM0583RNTC",
465                "classifications": [
466                    "cell line"
467                ],
468                "modifications": [
469                    {
470                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
471                        "modality": "prime editing",
472                        "status": "released",
473                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
474                    }
475                ],
476                "sample_terms": [
477                    {
478                        "@id": "/sample-terms/EFO_0001253/",
479                        "status": "released",
480                        "term_name": "THP-1"
481                    }
482                ],
483                "status": "released",
484                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
485                "taxa": "Homo sapiens"
486            },
487            {
488                "@id": "/in-vitro-systems/IGVFSM2895VEVU/",
489                "@type": [
490                    "InVitroSystem",
491                    "Biosample",
492                    "Sample",
493                    "Item"
494                ],
495                "accession": "IGVFSM2895VEVU",
496                "classifications": [
497                    "cell line"
498                ],
499                "modifications": [
500                    {
501                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
502                        "modality": "prime editing",
503                        "status": "released",
504                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
505                    }
506                ],
507                "sample_terms": [
508                    {
509                        "@id": "/sample-terms/EFO_0001253/",
510                        "status": "released",
511                        "term_name": "THP-1"
512                    }
513                ],
514                "status": "released",
515                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
516                "taxa": "Homo sapiens"
517            },
518            {
519                "@id": "/in-vitro-systems/IGVFSM8189JDTX/",
520                "@type": [
521                    "InVitroSystem",
522                    "Biosample",
523                    "Sample",
524                    "Item"
525                ],
526                "accession": "IGVFSM8189JDTX",
527                "classifications": [
528                    "cell line"
529                ],
530                "modifications": [
531                    {
532                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
533                        "modality": "prime editing",
534                        "status": "released",
535                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
536                    }
537                ],
538                "sample_terms": [
539                    {
540                        "@id": "/sample-terms/EFO_0001253/",
541                        "status": "released",
542                        "term_name": "THP-1"
543                    }
544                ],
545                "status": "released",
546                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
547                "taxa": "Homo sapiens"
548            },
549            {
550                "@id": "/in-vitro-systems/IGVFSM2812NEWC/",
551                "@type": [
552                    "InVitroSystem",
553                    "Biosample",
554                    "Sample",
555                    "Item"
556                ],
557                "accession": "IGVFSM2812NEWC",
558                "classifications": [
559                    "cell line"
560                ],
561                "modifications": [
562                    {
563                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
564                        "modality": "prime editing",
565                        "status": "released",
566                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
567                    }
568                ],
569                "sample_terms": [
570                    {
571                        "@id": "/sample-terms/EFO_0001253/",
572                        "status": "released",
573                        "term_name": "THP-1"
574                    }
575                ],
576                "status": "released",
577                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
578                "taxa": "Homo sapiens"
579            },
580            {
581                "@id": "/in-vitro-systems/IGVFSM1989ECAN/",
582                "@type": [
583                    "InVitroSystem",
584                    "Biosample",
585                    "Sample",
586                    "Item"
587                ],
588                "accession": "IGVFSM1989ECAN",
589                "classifications": [
590                    "cell line"
591                ],
592                "modifications": [
593                    {
594                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
595                        "modality": "prime editing",
596                        "status": "released",
597                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
598                    }
599                ],
600                "sample_terms": [
601                    {
602                        "@id": "/sample-terms/EFO_0001253/",
603                        "status": "released",
604                        "term_name": "THP-1"
605                    }
606                ],
607                "status": "released",
608                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
609                "taxa": "Homo sapiens"
610            },
611            {
612                "@id": "/in-vitro-systems/IGVFSM9808CICG/",
613                "@type": [
614                    "InVitroSystem",
615                    "Biosample",
616                    "Sample",
617                    "Item"
618                ],
619                "accession": "IGVFSM9808CICG",
620                "classifications": [
621                    "cell line"
622                ],
623                "modifications": [
624                    {
625                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
626                        "modality": "prime editing",
627                        "status": "released",
628                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
629                    }
630                ],
631                "sample_terms": [
632                    {
633                        "@id": "/sample-terms/EFO_0001253/",
634                        "status": "released",
635                        "term_name": "THP-1"
636                    }
637                ],
638                "status": "released",
639                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
640                "taxa": "Homo sapiens"
641            },
642            {
643                "@id": "/in-vitro-systems/IGVFSM7846WBRV/",
644                "@type": [
645                    "InVitroSystem",
646                    "Biosample",
647                    "Sample",
648                    "Item"
649                ],
650                "accession": "IGVFSM7846WBRV",
651                "classifications": [
652                    "cell line"
653                ],
654                "modifications": [
655                    {
656                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
657                        "modality": "prime editing",
658                        "status": "released",
659                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
660                    }
661                ],
662                "sample_terms": [
663                    {
664                        "@id": "/sample-terms/EFO_0001253/",
665                        "status": "released",
666                        "term_name": "THP-1"
667                    }
668                ],
669                "status": "released",
670                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
671                "taxa": "Homo sapiens"
672            },
673            {
674                "@id": "/in-vitro-systems/IGVFSM8173RIRG/",
675                "@type": [
676                    "InVitroSystem",
677                    "Biosample",
678                    "Sample",
679                    "Item"
680                ],
681                "accession": "IGVFSM8173RIRG",
682                "classifications": [
683                    "cell line"
684                ],
685                "modifications": [
686                    {
687                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
688                        "modality": "prime editing",
689                        "status": "released",
690                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
691                    }
692                ],
693                "sample_terms": [
694                    {
695                        "@id": "/sample-terms/EFO_0001253/",
696                        "status": "released",
697                        "term_name": "THP-1"
698                    }
699                ],
700                "status": "released",
701                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
702                "taxa": "Homo sapiens"
703            },
704            {
705                "@id": "/in-vitro-systems/IGVFSM4295RBJG/",
706                "@type": [
707                    "InVitroSystem",
708                    "Biosample",
709                    "Sample",
710                    "Item"
711                ],
712                "accession": "IGVFSM4295RBJG",
713                "classifications": [
714                    "cell line"
715                ],
716                "modifications": [
717                    {
718                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
719                        "modality": "prime editing",
720                        "status": "released",
721                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
722                    }
723                ],
724                "sample_terms": [
725                    {
726                        "@id": "/sample-terms/EFO_0001253/",
727                        "status": "released",
728                        "term_name": "THP-1"
729                    }
730                ],
731                "status": "released",
732                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
733                "taxa": "Homo sapiens"
734            },
735            {
736                "@id": "/in-vitro-systems/IGVFSM6376JXGZ/",
737                "@type": [
738                    "InVitroSystem",
739                    "Biosample",
740                    "Sample",
741                    "Item"
742                ],
743                "accession": "IGVFSM6376JXGZ",
744                "classifications": [
745                    "cell line"
746                ],
747                "modifications": [
748                    {
749                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
750                        "modality": "prime editing",
751                        "status": "released",
752                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
753                    }
754                ],
755                "sample_terms": [
756                    {
757                        "@id": "/sample-terms/EFO_0001253/",
758                        "status": "released",
759                        "term_name": "THP-1"
760                    }
761                ],
762                "status": "released",
763                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
764                "taxa": "Homo sapiens"
765            },
766            {
767                "@id": "/in-vitro-systems/IGVFSM1994AWYG/",
768                "@type": [
769                    "InVitroSystem",
770                    "Biosample",
771                    "Sample",
772                    "Item"
773                ],
774                "accession": "IGVFSM1994AWYG",
775                "classifications": [
776                    "cell line"
777                ],
778                "modifications": [
779                    {
780                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
781                        "modality": "prime editing",
782                        "status": "released",
783                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
784                    }
785                ],
786                "sample_terms": [
787                    {
788                        "@id": "/sample-terms/EFO_0001253/",
789                        "status": "released",
790                        "term_name": "THP-1"
791                    }
792                ],
793                "status": "released",
794                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
795                "taxa": "Homo sapiens"
796            },
797            {
798                "@id": "/in-vitro-systems/IGVFSM1018AFSU/",
799                "@type": [
800                    "InVitroSystem",
801                    "Biosample",
802                    "Sample",
803                    "Item"
804                ],
805                "accession": "IGVFSM1018AFSU",
806                "classifications": [
807                    "cell line"
808                ],
809                "modifications": [
810                    {
811                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
812                        "modality": "prime editing",
813                        "status": "released",
814                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
815                    }
816                ],
817                "sample_terms": [
818                    {
819                        "@id": "/sample-terms/EFO_0001253/",
820                        "status": "released",
821                        "term_name": "THP-1"
822                    }
823                ],
824                "status": "released",
825                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
826                "taxa": "Homo sapiens"
827            },
828            {
829                "@id": "/in-vitro-systems/IGVFSM5063WIJW/",
830                "@type": [
831                    "InVitroSystem",
832                    "Biosample",
833                    "Sample",
834                    "Item"
835                ],
836                "accession": "IGVFSM5063WIJW",
837                "classifications": [
838                    "cell line"
839                ],
840                "modifications": [
841                    {
842                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
843                        "modality": "prime editing",
844                        "status": "released",
845                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
846                    }
847                ],
848                "sample_terms": [
849                    {
850                        "@id": "/sample-terms/EFO_0001253/",
851                        "status": "released",
852                        "term_name": "THP-1"
853                    }
854                ],
855                "status": "released",
856                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
857                "taxa": "Homo sapiens"
858            },
859            {
860                "@id": "/in-vitro-systems/IGVFSM8988WXEB/",
861                "@type": [
862                    "InVitroSystem",
863                    "Biosample",
864                    "Sample",
865                    "Item"
866                ],
867                "accession": "IGVFSM8988WXEB",
868                "classifications": [
869                    "cell line"
870                ],
871                "modifications": [
872                    {
873                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
874                        "modality": "prime editing",
875                        "status": "released",
876                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
877                    }
878                ],
879                "sample_terms": [
880                    {
881                        "@id": "/sample-terms/EFO_0001253/",
882                        "status": "released",
883                        "term_name": "THP-1"
884                    }
885                ],
886                "status": "released",
887                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
888                "taxa": "Homo sapiens"
889            },
890            {
891                "@id": "/in-vitro-systems/IGVFSM1309CTNL/",
892                "@type": [
893                    "InVitroSystem",
894                    "Biosample",
895                    "Sample",
896                    "Item"
897                ],
898                "accession": "IGVFSM1309CTNL",
899                "classifications": [
900                    "cell line"
901                ],
902                "modifications": [
903                    {
904                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
905                        "modality": "prime editing",
906                        "status": "released",
907                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
908                    }
909                ],
910                "sample_terms": [
911                    {
912                        "@id": "/sample-terms/EFO_0001253/",
913                        "status": "released",
914                        "term_name": "THP-1"
915                    }
916                ],
917                "status": "released",
918                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
919                "taxa": "Homo sapiens"
920            },
921            {
922                "@id": "/in-vitro-systems/IGVFSM0994FYUT/",
923                "@type": [
924                    "InVitroSystem",
925                    "Biosample",
926                    "Sample",
927                    "Item"
928                ],
929                "accession": "IGVFSM0994FYUT",
930                "classifications": [
931                    "cell line"
932                ],
933                "modifications": [
934                    {
935                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
936                        "modality": "prime editing",
937                        "status": "released",
938                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
939                    }
940                ],
941                "sample_terms": [
942                    {
943                        "@id": "/sample-terms/EFO_0001253/",
944                        "status": "released",
945                        "term_name": "THP-1"
946                    }
947                ],
948                "status": "released",
949                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
950                "taxa": "Homo sapiens"
951            },
952            {
953                "@id": "/in-vitro-systems/IGVFSM8384KCKA/",
954                "@type": [
955                    "InVitroSystem",
956                    "Biosample",
957                    "Sample",
958                    "Item"
959                ],
960                "accession": "IGVFSM8384KCKA",
961                "classifications": [
962                    "cell line"
963                ],
964                "modifications": [
965                    {
966                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
967                        "modality": "prime editing",
968                        "status": "released",
969                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
970                    }
971                ],
972                "sample_terms": [
973                    {
974                        "@id": "/sample-terms/EFO_0001253/",
975                        "status": "released",
976                        "term_name": "THP-1"
977                    }
978                ],
979                "status": "released",
980                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
981                "taxa": "Homo sapiens"
982            },
983            {
984                "@id": "/in-vitro-systems/IGVFSM3490JPYE/",
985                "@type": [
986                    "InVitroSystem",
987                    "Biosample",
988                    "Sample",
989                    "Item"
990                ],
991                "accession": "IGVFSM3490JPYE",
992                "classifications": [
993                    "cell line"
994                ],
995                "modifications": [
996                    {
997                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
998                        "modality": "prime editing",
999                        "status": "released",
1000                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1001                    }
1002                ],
1003                "sample_terms": [
1004                    {
1005                        "@id": "/sample-terms/EFO_0001253/",
1006                        "status": "released",
1007                        "term_name": "THP-1"
1008                    }
1009                ],
1010                "status": "released",
1011                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1012                "taxa": "Homo sapiens"
1013            },
1014            {
1015                "@id": "/in-vitro-systems/IGVFSM1388TFMJ/",
1016                "@type": [
1017                    "InVitroSystem",
1018                    "Biosample",
1019                    "Sample",
1020                    "Item"
1021                ],
1022                "accession": "IGVFSM1388TFMJ",
1023                "classifications": [
1024                    "cell line"
1025                ],
1026                "modifications": [
1027                    {
1028                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1029                        "modality": "prime editing",
1030                        "status": "released",
1031                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1032                    }
1033                ],
1034                "sample_terms": [
1035                    {
1036                        "@id": "/sample-terms/EFO_0001253/",
1037                        "status": "released",
1038                        "term_name": "THP-1"
1039                    }
1040                ],
1041                "status": "released",
1042                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1043                "taxa": "Homo sapiens"
1044            },
1045            {
1046                "@id": "/in-vitro-systems/IGVFSM1355ITKK/",
1047                "@type": [
1048                    "InVitroSystem",
1049                    "Biosample",
1050                    "Sample",
1051                    "Item"
1052                ],
1053                "accession": "IGVFSM1355ITKK",
1054                "classifications": [
1055                    "cell line"
1056                ],
1057                "modifications": [
1058                    {
1059                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1060                        "modality": "prime editing",
1061                        "status": "released",
1062                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1063                    }
1064                ],
1065                "sample_terms": [
1066                    {
1067                        "@id": "/sample-terms/EFO_0001253/",
1068                        "status": "released",
1069                        "term_name": "THP-1"
1070                    }
1071                ],
1072                "status": "released",
1073                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1074                "taxa": "Homo sapiens"
1075            },
1076            {
1077                "@id": "/in-vitro-systems/IGVFSM2216EFEX/",
1078                "@type": [
1079                    "InVitroSystem",
1080                    "Biosample",
1081                    "Sample",
1082                    "Item"
1083                ],
1084                "accession": "IGVFSM2216EFEX",
1085                "classifications": [
1086                    "cell line"
1087                ],
1088                "modifications": [
1089                    {
1090                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1091                        "modality": "prime editing",
1092                        "status": "released",
1093                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1094                    }
1095                ],
1096                "sample_terms": [
1097                    {
1098                        "@id": "/sample-terms/EFO_0001253/",
1099                        "status": "released",
1100                        "term_name": "THP-1"
1101                    }
1102                ],
1103                "status": "released",
1104                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)",
1105                "taxa": "Homo sapiens"
1106            },
1107            {
1108                "@id": "/in-vitro-systems/IGVFSM7066SDHY/",
1109                "@type": [
1110                    "InVitroSystem",
1111                    "Biosample",
1112                    "Sample",
1113                    "Item"
1114                ],
1115                "accession": "IGVFSM7066SDHY",
1116                "classifications": [
1117                    "cell line"
1118                ],
1119                "modifications": [
1120                    {
1121                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1122                        "modality": "prime editing",
1123                        "status": "released",
1124                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1125                    }
1126                ],
1127                "sample_terms": [
1128                    {
1129                        "@id": "/sample-terms/EFO_0001253/",
1130                        "status": "released",
1131                        "term_name": "THP-1"
1132                    }
1133                ],
1134                "status": "released",
1135                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1136                "taxa": "Homo sapiens"
1137            },
1138            {
1139                "@id": "/in-vitro-systems/IGVFSM0320EORI/",
1140                "@type": [
1141                    "InVitroSystem",
1142                    "Biosample",
1143                    "Sample",
1144                    "Item"
1145                ],
1146                "accession": "IGVFSM0320EORI",
1147                "classifications": [
1148                    "cell line"
1149                ],
1150                "modifications": [
1151                    {
1152                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1153                        "modality": "prime editing",
1154                        "status": "released",
1155                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1156                    }
1157                ],
1158                "sample_terms": [
1159                    {
1160                        "@id": "/sample-terms/EFO_0001253/",
1161                        "status": "released",
1162                        "term_name": "THP-1"
1163                    }
1164                ],
1165                "status": "released",
1166                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1167                "taxa": "Homo sapiens"
1168            },
1169            {
1170                "@id": "/in-vitro-systems/IGVFSM4143IEHE/",
1171                "@type": [
1172                    "InVitroSystem",
1173                    "Biosample",
1174                    "Sample",
1175                    "Item"
1176                ],
1177                "accession": "IGVFSM4143IEHE",
1178                "classifications": [
1179                    "cell line"
1180                ],
1181                "modifications": [
1182                    {
1183                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1184                        "modality": "prime editing",
1185                        "status": "released",
1186                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1187                    }
1188                ],
1189                "sample_terms": [
1190                    {
1191                        "@id": "/sample-terms/EFO_0001253/",
1192                        "status": "released",
1193                        "term_name": "THP-1"
1194                    }
1195                ],
1196                "status": "released",
1197                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1198                "taxa": "Homo sapiens"
1199            },
1200            {
1201                "@id": "/in-vitro-systems/IGVFSM1606JQTG/",
1202                "@type": [
1203                    "InVitroSystem",
1204                    "Biosample",
1205                    "Sample",
1206                    "Item"
1207                ],
1208                "accession": "IGVFSM1606JQTG",
1209                "classifications": [
1210                    "cell line"
1211                ],
1212                "modifications": [
1213                    {
1214                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1215                        "modality": "prime editing",
1216                        "status": "released",
1217                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1218                    }
1219                ],
1220                "sample_terms": [
1221                    {
1222                        "@id": "/sample-terms/EFO_0001253/",
1223                        "status": "released",
1224                        "term_name": "THP-1"
1225                    }
1226                ],
1227                "status": "released",
1228                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1229                "taxa": "Homo sapiens"
1230            },
1231            {
1232                "@id": "/in-vitro-systems/IGVFSM0484FSRU/",
1233                "@type": [
1234                    "InVitroSystem",
1235                    "Biosample",
1236                    "Sample",
1237                    "Item"
1238                ],
1239                "accession": "IGVFSM0484FSRU",
1240                "classifications": [
1241                    "cell line"
1242                ],
1243                "modifications": [
1244                    {
1245                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1246                        "modality": "prime editing",
1247                        "status": "released",
1248                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1249                    }
1250                ],
1251                "sample_terms": [
1252                    {
1253                        "@id": "/sample-terms/EFO_0001253/",
1254                        "status": "released",
1255                        "term_name": "THP-1"
1256                    }
1257                ],
1258                "status": "released",
1259                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1260                "taxa": "Homo sapiens"
1261            },
1262            {
1263                "@id": "/in-vitro-systems/IGVFSM5557UHMD/",
1264                "@type": [
1265                    "InVitroSystem",
1266                    "Biosample",
1267                    "Sample",
1268                    "Item"
1269                ],
1270                "accession": "IGVFSM5557UHMD",
1271                "classifications": [
1272                    "cell line"
1273                ],
1274                "modifications": [
1275                    {
1276                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1277                        "modality": "prime editing",
1278                        "status": "released",
1279                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1280                    }
1281                ],
1282                "sample_terms": [
1283                    {
1284                        "@id": "/sample-terms/EFO_0001253/",
1285                        "status": "released",
1286                        "term_name": "THP-1"
1287                    }
1288                ],
1289                "status": "released",
1290                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1291                "taxa": "Homo sapiens"
1292            },
1293            {
1294                "@id": "/in-vitro-systems/IGVFSM9337QVAD/",
1295                "@type": [
1296                    "InVitroSystem",
1297                    "Biosample",
1298                    "Sample",
1299                    "Item"
1300                ],
1301                "accession": "IGVFSM9337QVAD",
1302                "classifications": [
1303                    "cell line"
1304                ],
1305                "modifications": [
1306                    {
1307                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1308                        "modality": "prime editing",
1309                        "status": "released",
1310                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1311                    }
1312                ],
1313                "sample_terms": [
1314                    {
1315                        "@id": "/sample-terms/EFO_0001253/",
1316                        "status": "released",
1317                        "term_name": "THP-1"
1318                    }
1319                ],
1320                "status": "released",
1321                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1322                "taxa": "Homo sapiens"
1323            },
1324            {
1325                "@id": "/in-vitro-systems/IGVFSM9234DKCR/",
1326                "@type": [
1327                    "InVitroSystem",
1328                    "Biosample",
1329                    "Sample",
1330                    "Item"
1331                ],
1332                "accession": "IGVFSM9234DKCR",
1333                "classifications": [
1334                    "cell line"
1335                ],
1336                "modifications": [
1337                    {
1338                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1339                        "modality": "prime editing",
1340                        "status": "released",
1341                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1342                    }
1343                ],
1344                "sample_terms": [
1345                    {
1346                        "@id": "/sample-terms/EFO_0001253/",
1347                        "status": "released",
1348                        "term_name": "THP-1"
1349                    }
1350                ],
1351                "status": "released",
1352                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1353                "taxa": "Homo sapiens"
1354            },
1355            {
1356                "@id": "/in-vitro-systems/IGVFSM7667TLNR/",
1357                "@type": [
1358                    "InVitroSystem",
1359                    "Biosample",
1360                    "Sample",
1361                    "Item"
1362                ],
1363                "accession": "IGVFSM7667TLNR",
1364                "classifications": [
1365                    "cell line"
1366                ],
1367                "modifications": [
1368                    {
1369                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1370                        "modality": "prime editing",
1371                        "status": "released",
1372                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1373                    }
1374                ],
1375                "sample_terms": [
1376                    {
1377                        "@id": "/sample-terms/EFO_0001253/",
1378                        "status": "released",
1379                        "term_name": "THP-1"
1380                    }
1381                ],
1382                "status": "released",
1383                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1384                "taxa": "Homo sapiens"
1385            },
1386            {
1387                "@id": "/in-vitro-systems/IGVFSM9316MGHL/",
1388                "@type": [
1389                    "InVitroSystem",
1390                    "Biosample",
1391                    "Sample",
1392                    "Item"
1393                ],
1394                "accession": "IGVFSM9316MGHL",
1395                "classifications": [
1396                    "cell line"
1397                ],
1398                "modifications": [
1399                    {
1400                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1401                        "modality": "prime editing",
1402                        "status": "released",
1403                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1404                    }
1405                ],
1406                "sample_terms": [
1407                    {
1408                        "@id": "/sample-terms/EFO_0001253/",
1409                        "status": "released",
1410                        "term_name": "THP-1"
1411                    }
1412                ],
1413                "status": "released",
1414                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1415                "taxa": "Homo sapiens"
1416            },
1417            {
1418                "@id": "/in-vitro-systems/IGVFSM0787QFVT/",
1419                "@type": [
1420                    "InVitroSystem",
1421                    "Biosample",
1422                    "Sample",
1423                    "Item"
1424                ],
1425                "accession": "IGVFSM0787QFVT",
1426                "classifications": [
1427                    "cell line"
1428                ],
1429                "modifications": [
1430                    {
1431                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1432                        "modality": "prime editing",
1433                        "status": "released",
1434                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1435                    }
1436                ],
1437                "sample_terms": [
1438                    {
1439                        "@id": "/sample-terms/EFO_0001253/",
1440                        "status": "released",
1441                        "term_name": "THP-1"
1442                    }
1443                ],
1444                "status": "released",
1445                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1446                "taxa": "Homo sapiens"
1447            },
1448            {
1449                "@id": "/in-vitro-systems/IGVFSM4973WSEU/",
1450                "@type": [
1451                    "InVitroSystem",
1452                    "Biosample",
1453                    "Sample",
1454                    "Item"
1455                ],
1456                "accession": "IGVFSM4973WSEU",
1457                "classifications": [
1458                    "cell line"
1459                ],
1460                "modifications": [
1461                    {
1462                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1463                        "modality": "prime editing",
1464                        "status": "released",
1465                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1466                    }
1467                ],
1468                "sample_terms": [
1469                    {
1470                        "@id": "/sample-terms/EFO_0001253/",
1471                        "status": "released",
1472                        "term_name": "THP-1"
1473                    }
1474                ],
1475                "status": "released",
1476                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1477                "taxa": "Homo sapiens"
1478            },
1479            {
1480                "@id": "/in-vitro-systems/IGVFSM1757XEWZ/",
1481                "@type": [
1482                    "InVitroSystem",
1483                    "Biosample",
1484                    "Sample",
1485                    "Item"
1486                ],
1487                "accession": "IGVFSM1757XEWZ",
1488                "classifications": [
1489                    "cell line"
1490                ],
1491                "modifications": [
1492                    {
1493                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1494                        "modality": "prime editing",
1495                        "status": "released",
1496                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1497                    }
1498                ],
1499                "sample_terms": [
1500                    {
1501                        "@id": "/sample-terms/EFO_0001253/",
1502                        "status": "released",
1503                        "term_name": "THP-1"
1504                    }
1505                ],
1506                "status": "released",
1507                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1508                "taxa": "Homo sapiens"
1509            },
1510            {
1511                "@id": "/in-vitro-systems/IGVFSM9690YXEE/",
1512                "@type": [
1513                    "InVitroSystem",
1514                    "Biosample",
1515                    "Sample",
1516                    "Item"
1517                ],
1518                "accession": "IGVFSM9690YXEE",
1519                "classifications": [
1520                    "cell line"
1521                ],
1522                "modifications": [
1523                    {
1524                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1525                        "modality": "prime editing",
1526                        "status": "released",
1527                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1528                    }
1529                ],
1530                "sample_terms": [
1531                    {
1532                        "@id": "/sample-terms/EFO_0001253/",
1533                        "status": "released",
1534                        "term_name": "THP-1"
1535                    }
1536                ],
1537                "status": "released",
1538                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1539                "taxa": "Homo sapiens"
1540            },
1541            {
1542                "@id": "/in-vitro-systems/IGVFSM2522SXJT/",
1543                "@type": [
1544                    "InVitroSystem",
1545                    "Biosample",
1546                    "Sample",
1547                    "Item"
1548                ],
1549                "accession": "IGVFSM2522SXJT",
1550                "classifications": [
1551                    "cell line"
1552                ],
1553                "modifications": [
1554                    {
1555                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1556                        "modality": "prime editing",
1557                        "status": "released",
1558                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1559                    }
1560                ],
1561                "sample_terms": [
1562                    {
1563                        "@id": "/sample-terms/EFO_0001253/",
1564                        "status": "released",
1565                        "term_name": "THP-1"
1566                    }
1567                ],
1568                "status": "released",
1569                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1570                "taxa": "Homo sapiens"
1571            },
1572            {
1573                "@id": "/in-vitro-systems/IGVFSM1133ETJG/",
1574                "@type": [
1575                    "InVitroSystem",
1576                    "Biosample",
1577                    "Sample",
1578                    "Item"
1579                ],
1580                "accession": "IGVFSM1133ETJG",
1581                "classifications": [
1582                    "cell line"
1583                ],
1584                "modifications": [
1585                    {
1586                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1587                        "modality": "prime editing",
1588                        "status": "released",
1589                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1590                    }
1591                ],
1592                "sample_terms": [
1593                    {
1594                        "@id": "/sample-terms/EFO_0001253/",
1595                        "status": "released",
1596                        "term_name": "THP-1"
1597                    }
1598                ],
1599                "status": "released",
1600                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1601                "taxa": "Homo sapiens"
1602            },
1603            {
1604                "@id": "/in-vitro-systems/IGVFSM9821UQTT/",
1605                "@type": [
1606                    "InVitroSystem",
1607                    "Biosample",
1608                    "Sample",
1609                    "Item"
1610                ],
1611                "accession": "IGVFSM9821UQTT",
1612                "classifications": [
1613                    "cell line"
1614                ],
1615                "modifications": [
1616                    {
1617                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1618                        "modality": "prime editing",
1619                        "status": "released",
1620                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1621                    }
1622                ],
1623                "sample_terms": [
1624                    {
1625                        "@id": "/sample-terms/EFO_0001253/",
1626                        "status": "released",
1627                        "term_name": "THP-1"
1628                    }
1629                ],
1630                "status": "released",
1631                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1632                "taxa": "Homo sapiens"
1633            },
1634            {
1635                "@id": "/in-vitro-systems/IGVFSM3137EVKW/",
1636                "@type": [
1637                    "InVitroSystem",
1638                    "Biosample",
1639                    "Sample",
1640                    "Item"
1641                ],
1642                "accession": "IGVFSM3137EVKW",
1643                "classifications": [
1644                    "cell line"
1645                ],
1646                "modifications": [
1647                    {
1648                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1649                        "modality": "prime editing",
1650                        "status": "released",
1651                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1652                    }
1653                ],
1654                "sample_terms": [
1655                    {
1656                        "@id": "/sample-terms/EFO_0001253/",
1657                        "status": "released",
1658                        "term_name": "THP-1"
1659                    }
1660                ],
1661                "status": "released",
1662                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1663                "taxa": "Homo sapiens"
1664            },
1665            {
1666                "@id": "/in-vitro-systems/IGVFSM1218VKDC/",
1667                "@type": [
1668                    "InVitroSystem",
1669                    "Biosample",
1670                    "Sample",
1671                    "Item"
1672                ],
1673                "accession": "IGVFSM1218VKDC",
1674                "classifications": [
1675                    "cell line"
1676                ],
1677                "modifications": [
1678                    {
1679                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1680                        "modality": "prime editing",
1681                        "status": "released",
1682                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1683                    }
1684                ],
1685                "sample_terms": [
1686                    {
1687                        "@id": "/sample-terms/EFO_0001253/",
1688                        "status": "released",
1689                        "term_name": "THP-1"
1690                    }
1691                ],
1692                "status": "released",
1693                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1694                "taxa": "Homo sapiens"
1695            },
1696            {
1697                "@id": "/in-vitro-systems/IGVFSM6928KZFH/",
1698                "@type": [
1699                    "InVitroSystem",
1700                    "Biosample",
1701                    "Sample",
1702                    "Item"
1703                ],
1704                "accession": "IGVFSM6928KZFH",
1705                "classifications": [
1706                    "cell line"
1707                ],
1708                "modifications": [
1709                    {
1710                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1711                        "modality": "prime editing",
1712                        "status": "released",
1713                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1714                    }
1715                ],
1716                "sample_terms": [
1717                    {
1718                        "@id": "/sample-terms/EFO_0001253/",
1719                        "status": "released",
1720                        "term_name": "THP-1"
1721                    }
1722                ],
1723                "status": "released",
1724                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1725                "taxa": "Homo sapiens"
1726            },
1727            {
1728                "@id": "/in-vitro-systems/IGVFSM3056BTTL/",
1729                "@type": [
1730                    "InVitroSystem",
1731                    "Biosample",
1732                    "Sample",
1733                    "Item"
1734                ],
1735                "accession": "IGVFSM3056BTTL",
1736                "classifications": [
1737                    "cell line"
1738                ],
1739                "modifications": [
1740                    {
1741                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1742                        "modality": "prime editing",
1743                        "status": "released",
1744                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1745                    }
1746                ],
1747                "sample_terms": [
1748                    {
1749                        "@id": "/sample-terms/EFO_0001253/",
1750                        "status": "released",
1751                        "term_name": "THP-1"
1752                    }
1753                ],
1754                "status": "released",
1755                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1756                "taxa": "Homo sapiens"
1757            },
1758            {
1759                "@id": "/in-vitro-systems/IGVFSM9746ERJH/",
1760                "@type": [
1761                    "InVitroSystem",
1762                    "Biosample",
1763                    "Sample",
1764                    "Item"
1765                ],
1766                "accession": "IGVFSM9746ERJH",
1767                "classifications": [
1768                    "cell line"
1769                ],
1770                "modifications": [
1771                    {
1772                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1773                        "modality": "prime editing",
1774                        "status": "released",
1775                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1776                    }
1777                ],
1778                "sample_terms": [
1779                    {
1780                        "@id": "/sample-terms/EFO_0001253/",
1781                        "status": "released",
1782                        "term_name": "THP-1"
1783                    }
1784                ],
1785                "status": "released",
1786                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1787                "taxa": "Homo sapiens"
1788            },
1789            {
1790                "@id": "/in-vitro-systems/IGVFSM1036VGPE/",
1791                "@type": [
1792                    "InVitroSystem",
1793                    "Biosample",
1794                    "Sample",
1795                    "Item"
1796                ],
1797                "accession": "IGVFSM1036VGPE",
1798                "classifications": [
1799                    "cell line"
1800                ],
1801                "modifications": [
1802                    {
1803                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1804                        "modality": "prime editing",
1805                        "status": "released",
1806                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1807                    }
1808                ],
1809                "sample_terms": [
1810                    {
1811                        "@id": "/sample-terms/EFO_0001253/",
1812                        "status": "released",
1813                        "term_name": "THP-1"
1814                    }
1815                ],
1816                "status": "released",
1817                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1818                "taxa": "Homo sapiens"
1819            },
1820            {
1821                "@id": "/in-vitro-systems/IGVFSM6445TGKO/",
1822                "@type": [
1823                    "InVitroSystem",
1824                    "Biosample",
1825                    "Sample",
1826                    "Item"
1827                ],
1828                "accession": "IGVFSM6445TGKO",
1829                "classifications": [
1830                    "cell line"
1831                ],
1832                "modifications": [
1833                    {
1834                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1835                        "modality": "prime editing",
1836                        "status": "released",
1837                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1838                    }
1839                ],
1840                "sample_terms": [
1841                    {
1842                        "@id": "/sample-terms/EFO_0001253/",
1843                        "status": "released",
1844                        "term_name": "THP-1"
1845                    }
1846                ],
1847                "status": "released",
1848                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1849                "taxa": "Homo sapiens"
1850            },
1851            {
1852                "@id": "/in-vitro-systems/IGVFSM1147YJAE/",
1853                "@type": [
1854                    "InVitroSystem",
1855                    "Biosample",
1856                    "Sample",
1857                    "Item"
1858                ],
1859                "accession": "IGVFSM1147YJAE",
1860                "classifications": [
1861                    "cell line"
1862                ],
1863                "modifications": [
1864                    {
1865                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1866                        "modality": "prime editing",
1867                        "status": "released",
1868                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1869                    }
1870                ],
1871                "sample_terms": [
1872                    {
1873                        "@id": "/sample-terms/EFO_0001253/",
1874                        "status": "released",
1875                        "term_name": "THP-1"
1876                    }
1877                ],
1878                "status": "released",
1879                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1880                "taxa": "Homo sapiens"
1881            },
1882            {
1883                "@id": "/in-vitro-systems/IGVFSM2582ALNT/",
1884                "@type": [
1885                    "InVitroSystem",
1886                    "Biosample",
1887                    "Sample",
1888                    "Item"
1889                ],
1890                "accession": "IGVFSM2582ALNT",
1891                "classifications": [
1892                    "cell line"
1893                ],
1894                "modifications": [
1895                    {
1896                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1897                        "modality": "prime editing",
1898                        "status": "released",
1899                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1900                    }
1901                ],
1902                "sample_terms": [
1903                    {
1904                        "@id": "/sample-terms/EFO_0001253/",
1905                        "status": "released",
1906                        "term_name": "THP-1"
1907                    }
1908                ],
1909                "status": "released",
1910                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1911                "taxa": "Homo sapiens"
1912            },
1913            {
1914                "@id": "/in-vitro-systems/IGVFSM8276OEZZ/",
1915                "@type": [
1916                    "InVitroSystem",
1917                    "Biosample",
1918                    "Sample",
1919                    "Item"
1920                ],
1921                "accession": "IGVFSM8276OEZZ",
1922                "classifications": [
1923                    "cell line"
1924                ],
1925                "modifications": [
1926                    {
1927                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1928                        "modality": "prime editing",
1929                        "status": "released",
1930                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1931                    }
1932                ],
1933                "sample_terms": [
1934                    {
1935                        "@id": "/sample-terms/EFO_0001253/",
1936                        "status": "released",
1937                        "term_name": "THP-1"
1938                    }
1939                ],
1940                "status": "released",
1941                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1942                "taxa": "Homo sapiens"
1943            },
1944            {
1945                "@id": "/in-vitro-systems/IGVFSM9994CSTP/",
1946                "@type": [
1947                    "InVitroSystem",
1948                    "Biosample",
1949                    "Sample",
1950                    "Item"
1951                ],
1952                "accession": "IGVFSM9994CSTP",
1953                "classifications": [
1954                    "cell line"
1955                ],
1956                "modifications": [
1957                    {
1958                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1959                        "modality": "prime editing",
1960                        "status": "released",
1961                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1962                    }
1963                ],
1964                "sample_terms": [
1965                    {
1966                        "@id": "/sample-terms/EFO_0001253/",
1967                        "status": "released",
1968                        "term_name": "THP-1"
1969                    }
1970                ],
1971                "status": "released",
1972                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 0-10% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
1973                "taxa": "Homo sapiens"
1974            },
1975            {
1976                "@id": "/in-vitro-systems/IGVFSM3596XEKI/",
1977                "@type": [
1978                    "InVitroSystem",
1979                    "Biosample",
1980                    "Sample",
1981                    "Item"
1982                ],
1983                "accession": "IGVFSM3596XEKI",
1984                "classifications": [
1985                    "cell line"
1986                ],
1987                "modifications": [
1988                    {
1989                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
1990                        "modality": "prime editing",
1991                        "status": "released",
1992                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
1993                    }
1994                ],
1995                "sample_terms": [
1996                    {
1997                        "@id": "/sample-terms/EFO_0001253/",
1998                        "status": "released",
1999                        "term_name": "THP-1"
2000                    }
2001                ],
2002                "status": "released",
2003                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2004                "taxa": "Homo sapiens"
2005            },
2006            {
2007                "@id": "/in-vitro-systems/IGVFSM0591ZRYW/",
2008                "@type": [
2009                    "InVitroSystem",
2010                    "Biosample",
2011                    "Sample",
2012                    "Item"
2013                ],
2014                "accession": "IGVFSM0591ZRYW",
2015                "classifications": [
2016                    "cell line"
2017                ],
2018                "modifications": [
2019                    {
2020                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2021                        "modality": "prime editing",
2022                        "status": "released",
2023                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2024                    }
2025                ],
2026                "sample_terms": [
2027                    {
2028                        "@id": "/sample-terms/EFO_0001253/",
2029                        "status": "released",
2030                        "term_name": "THP-1"
2031                    }
2032                ],
2033                "status": "released",
2034                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2035                "taxa": "Homo sapiens"
2036            },
2037            {
2038                "@id": "/in-vitro-systems/IGVFSM8604RBAL/",
2039                "@type": [
2040                    "InVitroSystem",
2041                    "Biosample",
2042                    "Sample",
2043                    "Item"
2044                ],
2045                "accession": "IGVFSM8604RBAL",
2046                "classifications": [
2047                    "cell line"
2048                ],
2049                "modifications": [
2050                    {
2051                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2052                        "modality": "prime editing",
2053                        "status": "released",
2054                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2055                    }
2056                ],
2057                "sample_terms": [
2058                    {
2059                        "@id": "/sample-terms/EFO_0001253/",
2060                        "status": "released",
2061                        "term_name": "THP-1"
2062                    }
2063                ],
2064                "status": "released",
2065                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2066                "taxa": "Homo sapiens"
2067            },
2068            {
2069                "@id": "/in-vitro-systems/IGVFSM1041JPLJ/",
2070                "@type": [
2071                    "InVitroSystem",
2072                    "Biosample",
2073                    "Sample",
2074                    "Item"
2075                ],
2076                "accession": "IGVFSM1041JPLJ",
2077                "classifications": [
2078                    "cell line"
2079                ],
2080                "modifications": [
2081                    {
2082                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2083                        "modality": "prime editing",
2084                        "status": "released",
2085                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2086                    }
2087                ],
2088                "sample_terms": [
2089                    {
2090                        "@id": "/sample-terms/EFO_0001253/",
2091                        "status": "released",
2092                        "term_name": "THP-1"
2093                    }
2094                ],
2095                "status": "released",
2096                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 35-45% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2097                "taxa": "Homo sapiens"
2098            },
2099            {
2100                "@id": "/in-vitro-systems/IGVFSM4767DNSQ/",
2101                "@type": [
2102                    "InVitroSystem",
2103                    "Biosample",
2104                    "Sample",
2105                    "Item"
2106                ],
2107                "accession": "IGVFSM4767DNSQ",
2108                "classifications": [
2109                    "cell line"
2110                ],
2111                "modifications": [
2112                    {
2113                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2114                        "modality": "prime editing",
2115                        "status": "released",
2116                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2117                    }
2118                ],
2119                "sample_terms": [
2120                    {
2121                        "@id": "/sample-terms/EFO_0001253/",
2122                        "status": "released",
2123                        "term_name": "THP-1"
2124                    }
2125                ],
2126                "status": "released",
2127                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2128                "taxa": "Homo sapiens"
2129            },
2130            {
2131                "@id": "/in-vitro-systems/IGVFSM7075GWHP/",
2132                "@type": [
2133                    "InVitroSystem",
2134                    "Biosample",
2135                    "Sample",
2136                    "Item"
2137                ],
2138                "accession": "IGVFSM7075GWHP",
2139                "classifications": [
2140                    "cell line"
2141                ],
2142                "modifications": [
2143                    {
2144                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2145                        "modality": "prime editing",
2146                        "status": "released",
2147                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2148                    }
2149                ],
2150                "sample_terms": [
2151                    {
2152                        "@id": "/sample-terms/EFO_0001253/",
2153                        "status": "released",
2154                        "term_name": "THP-1"
2155                    }
2156                ],
2157                "status": "released",
2158                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2159                "taxa": "Homo sapiens"
2160            },
2161            {
2162                "@id": "/in-vitro-systems/IGVFSM4555JSOF/",
2163                "@type": [
2164                    "InVitroSystem",
2165                    "Biosample",
2166                    "Sample",
2167                    "Item"
2168                ],
2169                "accession": "IGVFSM4555JSOF",
2170                "classifications": [
2171                    "cell line"
2172                ],
2173                "modifications": [
2174                    {
2175                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2176                        "modality": "prime editing",
2177                        "status": "released",
2178                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2179                    }
2180                ],
2181                "sample_terms": [
2182                    {
2183                        "@id": "/sample-terms/EFO_0001253/",
2184                        "status": "released",
2185                        "term_name": "THP-1"
2186                    }
2187                ],
2188                "status": "released",
2189                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2190                "taxa": "Homo sapiens"
2191            },
2192            {
2193                "@id": "/in-vitro-systems/IGVFSM8920YWJY/",
2194                "@type": [
2195                    "InVitroSystem",
2196                    "Biosample",
2197                    "Sample",
2198                    "Item"
2199                ],
2200                "accession": "IGVFSM8920YWJY",
2201                "classifications": [
2202                    "cell line"
2203                ],
2204                "modifications": [
2205                    {
2206                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2207                        "modality": "prime editing",
2208                        "status": "released",
2209                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2210                    }
2211                ],
2212                "sample_terms": [
2213                    {
2214                        "@id": "/sample-terms/EFO_0001253/",
2215                        "status": "released",
2216                        "term_name": "THP-1"
2217                    }
2218                ],
2219                "status": "released",
2220                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2221                "taxa": "Homo sapiens"
2222            },
2223            {
2224                "@id": "/in-vitro-systems/IGVFSM7879WOKC/",
2225                "@type": [
2226                    "InVitroSystem",
2227                    "Biosample",
2228                    "Sample",
2229                    "Item"
2230                ],
2231                "accession": "IGVFSM7879WOKC",
2232                "classifications": [
2233                    "cell line"
2234                ],
2235                "modifications": [
2236                    {
2237                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2238                        "modality": "prime editing",
2239                        "status": "released",
2240                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2241                    }
2242                ],
2243                "sample_terms": [
2244                    {
2245                        "@id": "/sample-terms/EFO_0001253/",
2246                        "status": "released",
2247                        "term_name": "THP-1"
2248                    }
2249                ],
2250                "status": "released",
2251                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 80-90% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2252                "taxa": "Homo sapiens"
2253            },
2254            {
2255                "@id": "/in-vitro-systems/IGVFSM0226JSRH/",
2256                "@type": [
2257                    "InVitroSystem",
2258                    "Biosample",
2259                    "Sample",
2260                    "Item"
2261                ],
2262                "accession": "IGVFSM0226JSRH",
2263                "classifications": [
2264                    "cell line"
2265                ],
2266                "modifications": [
2267                    {
2268                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2269                        "modality": "prime editing",
2270                        "status": "released",
2271                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2272                    }
2273                ],
2274                "sample_terms": [
2275                    {
2276                        "@id": "/sample-terms/EFO_0001253/",
2277                        "status": "released",
2278                        "term_name": "THP-1"
2279                    }
2280                ],
2281                "status": "released",
2282                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2283                "taxa": "Homo sapiens"
2284            },
2285            {
2286                "@id": "/in-vitro-systems/IGVFSM0595JWOO/",
2287                "@type": [
2288                    "InVitroSystem",
2289                    "Biosample",
2290                    "Sample",
2291                    "Item"
2292                ],
2293                "accession": "IGVFSM0595JWOO",
2294                "classifications": [
2295                    "cell line"
2296                ],
2297                "modifications": [
2298                    {
2299                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2300                        "modality": "prime editing",
2301                        "status": "released",
2302                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2303                    }
2304                ],
2305                "sample_terms": [
2306                    {
2307                        "@id": "/sample-terms/EFO_0001253/",
2308                        "status": "released",
2309                        "term_name": "THP-1"
2310                    }
2311                ],
2312                "status": "released",
2313                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2314                "taxa": "Homo sapiens"
2315            },
2316            {
2317                "@id": "/in-vitro-systems/IGVFSM1400DZMP/",
2318                "@type": [
2319                    "InVitroSystem",
2320                    "Biosample",
2321                    "Sample",
2322                    "Item"
2323                ],
2324                "accession": "IGVFSM1400DZMP",
2325                "classifications": [
2326                    "cell line"
2327                ],
2328                "modifications": [
2329                    {
2330                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2331                        "modality": "prime editing",
2332                        "status": "released",
2333                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2334                    }
2335                ],
2336                "sample_terms": [
2337                    {
2338                        "@id": "/sample-terms/EFO_0001253/",
2339                        "status": "released",
2340                        "term_name": "THP-1"
2341                    }
2342                ],
2343                "status": "released",
2344                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2345                "taxa": "Homo sapiens"
2346            },
2347            {
2348                "@id": "/in-vitro-systems/IGVFSM2043RUDS/",
2349                "@type": [
2350                    "InVitroSystem",
2351                    "Biosample",
2352                    "Sample",
2353                    "Item"
2354                ],
2355                "accession": "IGVFSM2043RUDS",
2356                "classifications": [
2357                    "cell line"
2358                ],
2359                "modifications": [
2360                    {
2361                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2362                        "modality": "prime editing",
2363                        "status": "released",
2364                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2365                    }
2366                ],
2367                "sample_terms": [
2368                    {
2369                        "@id": "/sample-terms/EFO_0001253/",
2370                        "status": "released",
2371                        "term_name": "THP-1"
2372                    }
2373                ],
2374                "status": "released",
2375                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 11-20% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2376                "taxa": "Homo sapiens"
2377            },
2378            {
2379                "@id": "/in-vitro-systems/IGVFSM9849CZIJ/",
2380                "@type": [
2381                    "InVitroSystem",
2382                    "Biosample",
2383                    "Sample",
2384                    "Item"
2385                ],
2386                "accession": "IGVFSM9849CZIJ",
2387                "classifications": [
2388                    "cell line"
2389                ],
2390                "modifications": [
2391                    {
2392                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2393                        "modality": "prime editing",
2394                        "status": "released",
2395                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2396                    }
2397                ],
2398                "sample_terms": [
2399                    {
2400                        "@id": "/sample-terms/EFO_0001253/",
2401                        "status": "released",
2402                        "term_name": "THP-1"
2403                    }
2404                ],
2405                "status": "released",
2406                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 90-100% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2407                "taxa": "Homo sapiens"
2408            },
2409            {
2410                "@id": "/in-vitro-systems/IGVFSM3814ESVL/",
2411                "@type": [
2412                    "InVitroSystem",
2413                    "Biosample",
2414                    "Sample",
2415                    "Item"
2416                ],
2417                "accession": "IGVFSM3814ESVL",
2418                "classifications": [
2419                    "cell line"
2420                ],
2421                "modifications": [
2422                    {
2423                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2424                        "modality": "prime editing",
2425                        "status": "released",
2426                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2427                    }
2428                ],
2429                "sample_terms": [
2430                    {
2431                        "@id": "/sample-terms/EFO_0001253/",
2432                        "status": "released",
2433                        "term_name": "THP-1"
2434                    }
2435                ],
2436                "status": "released",
2437                "summary": "Homo sapiens (male) THP-1 cell line modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2438                "taxa": "Homo sapiens"
2439            },
2440            {
2441                "@id": "/in-vitro-systems/IGVFSM0046YFNI/",
2442                "@type": [
2443                    "InVitroSystem",
2444                    "Biosample",
2445                    "Sample",
2446                    "Item"
2447                ],
2448                "accession": "IGVFSM0046YFNI",
2449                "classifications": [
2450                    "cell line"
2451                ],
2452                "modifications": [
2453                    {
2454                        "@id": "/crispr-modifications/fc6bc0b3-a064-47d0-b95d-a9af14bb1624/",
2455                        "modality": "prime editing",
2456                        "status": "released",
2457                        "summary": "CRISPR prime editing Sp-nCas9-M-MLV RT (PE2)"
2458                    }
2459                ],
2460                "sample_terms": [
2461                    {
2462                        "@id": "/sample-terms/EFO_0001253/",
2463                        "status": "released",
2464                        "term_name": "THP-1"
2465                    }
2466                ],
2467                "status": "released",
2468                "summary": "Homo sapiens (male) THP-1 cell line (sorting details: FACS bin for 55-65% expression of PPIF) modified with CRISPR prime editing Sp-nCas9-M-MLV RT (PE2), transduced (lentivirus) with a guide library",
2469                "taxa": "Homo sapiens"
2470            }
2471        ],
2472        "status": "released",
2473        "summary": "CRISPR prime editing Variant-EFFECTS targeting PPIF integrating a guide (sgRNA) library targeting sequence variants in a genomic locus"
2474    },
2475    "file_size": 2768,
2476    "gene_list_for": [],
2477    "href": "/tabular-files/IGVFFI4057VSBO/@@download/IGVFFI4057VSBO.tsv.gz",
2478    "input_file_for": [],
2479    "integrated_in": [],
2480    "lab": {
2481        "@id": "/labs/jesse-engreitz/",
2482        "title": "Jesse Engreitz, Stanford"
2483    },
2484    "loci_list_for": [],
2485    "md5sum": "222e73a89c818aa9888bb3c004857bdb",
2486    "primer_design_for": [],
2487    "quality_metrics": [],
2488    "s3_uri": "s3://igvf-files/2025/03/29/df56c015-6649-4156-bf1e-1680f1b6bd38/IGVFFI4057VSBO.tsv.gz",
2489    "schema_version": "15",
2490    "status": "preview",
2491    "submitted_by": {
2492        "@id": "/users/f9e7cd82-a407-4a20-89ee-f4dc668b0cbe/",
2493        "title": "Michael Montgomery"
2494    },
2495    "submitted_file_name": "PPIF_promoter_8mer_insertion_THP1_VariantEffectsFile.tsv.gz",
2496    "submitter_comment": "The original outputs from the Variant-EFFECTS pipeline report VariantIDs in the hg19 format. To obtain the standardized variant information provided in this file, hg19 coordinates were lifted to hg38 using the UCSC LiftOver tool (https://genome.ucsc.edu/cgi-bin/hgLiftOver). Then, canonical, validated SPDIs were generated and validated using the igvf_spdi_demo tool (https://github.com/mikelove/igvf_spdi_demo).",
2497    "summary": "GRCh38 variant effects",
2498    "upload_status": "validated",
2499    "uuid": "df56c015-6649-4156-bf1e-1680f1b6bd38"
2500}