IGVFDS9674AATW

released
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        "title": "High-Throughput Functional Annotation of Gene Regulatory Elements and Variants Critical to Complex Cellular Phenotypes"
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        "/analysis-sets/IGVFDS3319RFFN/"
    ],
    "lab": {
        "@id": "/labs/charles-gersbach/",
        "title": "Charles Gersbach, Duke"
    },
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    "preferred_assay_title": "Perturb-seq",
    "protocols": [
        "https://www.protocols.io/view/perturb-seq-characterizing-regulators-of-t-cell-fu-c5s9y6h6",
        "https://www.protocols.io/view/crispri-tiling-screens-c5rby52n"
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            "publication_identifiers": [
                "PMID:37945901",
                "doi:10.1038/s41588-023-01554-0",
                "PMCID:PMC10703699"
            ],
            "status": "released"
        }
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    "release_timestamp": "2024-10-18T19:50:07.271031+00:00",
    "samples": [
        {
            "@id": "/primary-cells/IGVFSM5189UBOI/",
            "@type": [
                "PrimaryCell",
                "Biosample",
                "Sample",
                "Item"
            ],
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            "aliases": [
                "charles-gersbach:cd8-tcells-primary-cell-crispri-rep3"
            ],
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                "primary cell"
            ],
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                {
                    "@id": "/construct-library-sets/IGVFDS0821YMMV/",
                    "accession": "IGVFDS0821YMMV",
                    "file_set_type": "guide library",
                    "small_scale_gene_list": [
                        {
                            "@id": "/genes/ENSG00000156127/",
                            "geneid": "ENSG00000156127",
                            "name": "basic leucine zipper ATF-like transcription factor",
                            "status": "released",
                            "summary": "BATF - ENSG00000156127 (Homo sapiens)",
                            "symbol": "BATF"
                        },
                        {
                            "@id": "/genes/ENSG00000123685/",
                            "geneid": "ENSG00000123685",
                            "name": "basic leucine zipper ATF-like transcription factor 3",
                            "status": "released",
                            "summary": "BATF3 - ENSG00000123685 (Homo sapiens)",
                            "symbol": "BATF3"
                        },
                        {
                            "@id": "/genes/ENSG00000134107/",
                            "geneid": "ENSG00000134107",
                            "name": "basic helix-loop-helix family member e40",
                            "status": "released",
                            "summary": "BHLHE40 - ENSG00000134107 (Homo sapiens)",
                            "symbol": "BHLHE40"
                        },
                        {
                            "@id": "/genes/ENSG00000095794/",
                            "geneid": "ENSG00000095794",
                            "name": "cAMP responsive element modulator",
                            "status": "released",
                            "summary": "CREM - ENSG00000095794 (Homo sapiens)",
                            "symbol": "CREM"
                        },
                        {
                            "@id": "/genes/ENSG00000163508/",
                            "geneid": "ENSG00000163508",
                            "name": "eomesodermin",
                            "status": "released",
                            "summary": "EOMES - ENSG00000163508 (Homo sapiens)",
                            "symbol": "EOMES"
                        },
                        {
                            "@id": "/genes/ENSG00000151702/",
                            "geneid": "ENSG00000151702",
                            "name": "Fli-1 proto-oncogene, ETS transcription factor",
                            "status": "released",
                            "summary": "FLI1 - ENSG00000151702 (Homo sapiens)",
                            "symbol": "FLI1"
                        },
                        {
                            "@id": "/genes/ENSG00000186564/",
                            "geneid": "ENSG00000186564",
                            "name": "forkhead box D2",
                            "status": "released",
                            "summary": "FOXD2 - ENSG00000186564 (Homo sapiens)",
                            "symbol": "FOXD2"
                        },
                        {
                            "@id": "/genes/ENSG00000150907/",
                            "geneid": "ENSG00000150907",
                            "name": "forkhead box O1",
                            "status": "released",
                            "summary": "FOXO1 - ENSG00000150907 (Homo sapiens)",
                            "symbol": "FOXO1"
                        },
                        {
                            "@id": "/genes/ENSG00000154727/",
                            "geneid": "ENSG00000154727",
                            "name": "GA binding protein transcription factor subunit alpha",
                            "status": "released",
                            "summary": "GABPA - ENSG00000154727 (Homo sapiens)",
                            "symbol": "GABPA"
                        },
                        {
                            "@id": "/genes/ENSG00000177374/",
                            "geneid": "ENSG00000177374",
                            "name": "HIC ZBTB transcriptional repressor 1",
                            "status": "released",
                            "summary": "HIC1 - ENSG00000177374 (Homo sapiens)",
                            "symbol": "HIC1"
                        },
                        {
                            "@id": "/genes/ENSG00000168310/",
                            "geneid": "ENSG00000168310",
                            "name": "interferon regulatory factor 2",
                            "status": "released",
                            "summary": "IRF2 - ENSG00000168310 (Homo sapiens)",
                            "symbol": "IRF2"
                        },
                        {
                            "@id": "/genes/ENSG00000177606/",
                            "geneid": "ENSG00000177606",
                            "name": "Jun proto-oncogene, AP-1 transcription factor subunit",
                            "status": "released",
                            "summary": "JUN - ENSG00000177606 (Homo sapiens)",
                            "symbol": "JUN"
                        },
                        {
                            "@id": "/genes/ENSG00000118513/",
                            "geneid": "ENSG00000118513",
                            "name": "MYB proto-oncogene, transcription factor",
                            "status": "released",
                            "summary": "MYB - ENSG00000118513 (Homo sapiens)",
                            "symbol": "MYB"
                        },
                        {
                            "@id": "/genes/ENSG00000072736/",
                            "geneid": "ENSG00000072736",
                            "name": "nuclear factor of activated T cells 3",
                            "status": "released",
                            "summary": "NFATC3 - ENSG00000072736 (Homo sapiens)",
                            "symbol": "NFATC3"
                        },
                        {
                            "@id": "/genes/ENSG00000082641/",
                            "geneid": "ENSG00000082641",
                            "name": "NFE2 like bZIP transcription factor 1",
                            "status": "released",
                            "summary": "NFE2L1 - ENSG00000082641 (Homo sapiens)",
                            "symbol": "NFE2L1"
                        },
                        {
                            "@id": "/genes/ENSG00000126368/",
                            "geneid": "ENSG00000126368",
                            "name": "nuclear receptor subfamily 1 group D member 1",
                            "status": "released",
                            "summary": "NR1D1 - ENSG00000126368 (Homo sapiens)",
                            "symbol": "NR1D1"
                        },
                        {
                            "@id": "/genes/ENSG00000123358/",
                            "geneid": "ENSG00000123358",
                            "name": "nuclear receptor subfamily 4 group A member 1",
                            "status": "released",
                            "summary": "NR4A1 - ENSG00000123358 (Homo sapiens)",
                            "symbol": "NR4A1"
                        },
                        {
                            "@id": "/genes/ENSG00000143190/",
                            "geneid": "ENSG00000143190",
                            "name": "POU class 2 homeobox 1",
                            "status": "released",
                            "summary": "POU2F1 - ENSG00000143190 (Homo sapiens)",
                            "symbol": "POU2F1"
                        },
                        {
                            "@id": "/genes/ENSG00000124782/",
                            "geneid": "ENSG00000124782",
                            "name": "ras responsive element binding protein 1",
                            "status": "released",
                            "summary": "RREB1 - ENSG00000124782 (Homo sapiens)",
                            "symbol": "RREB1"
                        },
                        {
                            "@id": "/genes/ENSG00000152284/",
                            "geneid": "ENSG00000152284",
                            "name": "transcription factor 7 like 1",
                            "status": "released",
                            "summary": "TCF7L1 - ENSG00000152284 (Homo sapiens)",
                            "symbol": "TCF7L1"
                        },
                        {
                            "@id": "/genes/ENSG00000184517/",
                            "geneid": "ENSG00000184517",
                            "name": "ZFP1 zinc finger protein",
                            "status": "released",
                            "summary": "ZFP1 - ENSG00000184517 (Homo sapiens)",
                            "symbol": "ZFP1"
                        },
                        {
                            "@id": "/genes/ENSG00000112182/",
                            "geneid": "ENSG00000112182",
                            "name": "BTB domain and CNC homolog 2",
                            "status": "released",
                            "summary": "BACH2 - ENSG00000112182 (Homo sapiens)",
                            "symbol": "BACH2"
                        },
                        {
                            "@id": "/genes/ENSG00000127528/",
                            "geneid": "ENSG00000127528",
                            "name": "KLF transcription factor 2",
                            "status": "released",
                            "summary": "KLF2 - ENSG00000127528 (Homo sapiens)",
                            "symbol": "KLF2"
                        },
                        {
                            "@id": "/genes/ENSG00000130816/",
                            "geneid": "ENSG00000130816",
                            "name": "DNA methyltransferase 1",
                            "status": "released",
                            "summary": "DNMT1 - ENSG00000130816 (Homo sapiens)",
                            "symbol": "DNMT1"
                        }
                    ],
                    "status": "released",
                    "summary": "guide (sgRNA) library targeting transcription start sites in 24 genes"
                }
            ],
            "modifications": [
                {
                    "@id": "/crispr-modifications/95393c9a-637d-43f6-baf9-662e45d28d61/",
                    "modality": "interference",
                    "status": "released"
                }
            ],
            "sample_terms": [
                {
                    "@id": "/sample-terms/CL_0000909/",
                    "@type": [
                        "SampleTerm",
                        "OntologyTerm",
                        "Item"
                    ],
                    "status": "released",
                    "summary": "CD8-positive, alpha-beta memory T cell",
                    "term_name": "CD8-positive, alpha-beta memory T cell"
                }
            ],
            "status": "released",
            "summary": "CD8-positive, alpha-beta memory T cell, Homo sapiens modified with CRISPRi Sa-dCas9, transduced (lentivirus) with a guide library (MOI of 0.4)",
            "taxa": "Homo sapiens"
        }
    ],
    "schema_version": "23",
    "status": "released",
    "submitted_by": {
        "@id": "/users/29f5f78d-ac90-421e-90c6-a90e1dc407a7/",
        "title": "Alejandro Barrera"
    },
    "submitted_files_timestamp": "2023-11-09T01:07:05.239635+00:00",
    "summary": "CRISPR interference Perturb-seq integrating a guide (sgRNA) library targeting transcription start sites in 24 genes",
    "uuid": "7834c361-d558-42d5-98a1-91b2219b3c30"
}