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HepG2 — IGVFSM0239RDRJ

released
Summary
HepG2 cell line, male, Homo sapiens (sorting details: Sorted for Bottom 20% LDL-C uptake) modified with CRISPR base editing SpRY-ABE8e, transduced (lentivirus) with a guide library (MOI of 0.5)
Sample Terms
Classification
cell line
Sex
male
Age
unknown
Taxa
Homo sapiens
Description
Sorted for Bottom 20% LDL-C uptake
Sources
Richard Sherwood, Brigham and Women's Hospital
Sorted From Sample
IGVFSM7036PBYG Sorted for Bottom 20% LDL-C uptake
Aliases
richard-sherwood:18loci_uptake_Rep1_bottom20_ivs

Donors

1 item
Accession
Aliases
Sex
Taxa
  • igvf:donor_of_HepG2
male
Homo sapiens

File Sets

2 items
CRISPR base editing FACS screen: guide quantifications, variant effects
  • richard-sherwood:18loci_ABE_LDLuptake_bean_analysis_set
Richard Sherwood, Brigham and Women's Hospital
CRISPR base editing FACS screen integrating a guide (sgRNA) library targeting phenotype-associated variants genome-wide
  • richard-sherwood:18loci_uptake_Rep1_bottom20_ms
Richard Sherwood, Brigham and Women's Hospital

Modifications

1 item
Summary
Modality
Activation
base editing

Attribution

Award
HG012010
Principal Investigator(s)
Contact P.I.
Luca Pinello
Lab
Richard Sherwood, Brigham and Women's Hospital