{
"@context": "/terms/",
"@id": "/crispr-modifications/b4bc725a-8eeb-4180-9789-bece3516c0c1/",
"@type": [
"CrisprModification",
"Modification",
"Item"
],
"activated": true,
"activating_agent_term_id": "CHEBI:50845",
"activating_agent_term_name": "doxycycline",
"aliases": [
"igvf:replacement_of_2ba01755-df67-453b-b047-f7cdba236665",
"jesse-engreitz:modification-teloHAEC-dCas9-KRAB"
],
"audit": {},
"award": {
"@id": "/awards/HG011972/",
"component": "functional characterization"
},
"biosamples_modified": [
"/in-vitro-systems/IGVFSM5826EWDE/",
"/in-vitro-systems/IGVFSM6912FONC/",
"/in-vitro-systems/IGVFSM9056OSKC/",
"/in-vitro-systems/IGVFSM7319EZLZ/",
"/in-vitro-systems/IGVFSM5229SOKC/",
"/in-vitro-systems/IGVFSM7436UMQD/",
"/in-vitro-systems/IGVFSM9579BBFC/",
"/in-vitro-systems/IGVFSM1034FQDF/",
"/in-vitro-systems/IGVFSM5424HTHI/",
"/in-vitro-systems/IGVFSM2326VRBK/",
"/in-vitro-systems/IGVFSM8115WXZU/",
"/in-vitro-systems/IGVFSM6792NCMN/",
"/in-vitro-systems/IGVFSM6408QEFG/",
"/in-vitro-systems/IGVFSM0599MHTG/",
"/in-vitro-systems/IGVFSM9488LHID/",
"/in-vitro-systems/IGVFSM8817SMTB/",
"/in-vitro-systems/IGVFSM1237FNBR/",
"/in-vitro-systems/IGVFSM2880OLBN/",
"/in-vitro-systems/IGVFSM6404DFQW/",
"/in-vitro-systems/IGVFSM6082DZRY/",
"/in-vitro-systems/IGVFSM1476YHNC/",
"/in-vitro-systems/IGVFSM6512KVQX/",
"/in-vitro-systems/IGVFSM7987ARAX/",
"/in-vitro-systems/IGVFSM6823DARA/",
"/in-vitro-systems/IGVFSM9750UXVD/",
"/in-vitro-systems/IGVFSM6969BXDT/",
"/in-vitro-systems/IGVFSM3814HZQI/",
"/in-vitro-systems/IGVFSM3700IHHL/",
"/in-vitro-systems/IGVFSM1061NWCP/",
"/in-vitro-systems/IGVFSM0862BZMH/",
"/in-vitro-systems/IGVFSM7408HYIB/",
"/in-vitro-systems/IGVFSM9054OJLH/",
"/in-vitro-systems/IGVFSM0914ERRM/",
"/in-vitro-systems/IGVFSM2486RPXY/",
"/in-vitro-systems/IGVFSM2756NFXE/",
"/in-vitro-systems/IGVFSM8121JQAK/",
"/in-vitro-systems/IGVFSM7992INYA/",
"/in-vitro-systems/IGVFSM4987QNQG/",
"/in-vitro-systems/IGVFSM4347MQFL/",
"/in-vitro-systems/IGVFSM7589OEYV/",
"/in-vitro-systems/IGVFSM3948PYPE/",
"/in-vitro-systems/IGVFSM0634QOST/",
"/in-vitro-systems/IGVFSM2673TSAF/",
"/in-vitro-systems/IGVFSM2155YTIW/",
"/in-vitro-systems/IGVFSM9485EHBX/",
"/in-vitro-systems/IGVFSM0897QVAK/",
"/in-vitro-systems/IGVFSM3472QIPU/",
"/in-vitro-systems/IGVFSM0672KXTP/",
"/in-vitro-systems/IGVFSM4227JQMA/",
"/in-vitro-systems/IGVFSM7134FIHW/",
"/in-vitro-systems/IGVFSM9689NFEU/",
"/in-vitro-systems/IGVFSM3508ZAFL/",
"/in-vitro-systems/IGVFSM0249YRUJ/",
"/in-vitro-systems/IGVFSM0180ODAW/",
"/in-vitro-systems/IGVFSM7471WJWF/",
"/in-vitro-systems/IGVFSM3812UYWH/",
"/in-vitro-systems/IGVFSM1575CPXR/",
"/in-vitro-systems/IGVFSM3104QEEP/",
"/in-vitro-systems/IGVFSM9362CZWG/",
"/in-vitro-systems/IGVFSM4878HUHM/",
"/in-vitro-systems/IGVFSM6467VTYE/",
"/in-vitro-systems/IGVFSM6909JYCD/",
"/in-vitro-systems/IGVFSM0912IPPR/",
"/in-vitro-systems/IGVFSM4464SPLF/",
"/in-vitro-systems/IGVFSM4675JUYE/",
"/in-vitro-systems/IGVFSM3569XFKY/",
"/in-vitro-systems/IGVFSM1085KVBF/",
"/in-vitro-systems/IGVFSM0325PTVL/",
"/in-vitro-systems/IGVFSM5205HIZS/",
"/in-vitro-systems/IGVFSM8559QOCC/",
"/in-vitro-systems/IGVFSM3988VBUB/",
"/in-vitro-systems/IGVFSM4639DMNG/",
"/in-vitro-systems/IGVFSM6643KIQQ/",
"/in-vitro-systems/IGVFSM3079JHCQ/",
"/in-vitro-systems/IGVFSM5877PFFV/",
"/in-vitro-systems/IGVFSM4345IGSA/",
"/in-vitro-systems/IGVFSM4978VPUD/",
"/in-vitro-systems/IGVFSM7665HTFX/",
"/in-vitro-systems/IGVFSM6272EHGA/",
"/in-vitro-systems/IGVFSM6249JKCM/",
"/in-vitro-systems/IGVFSM9019CRXH/",
"/in-vitro-systems/IGVFSM9151FQCE/",
"/in-vitro-systems/IGVFSM0962TVTG/",
"/in-vitro-systems/IGVFSM6891FDIO/",
"/in-vitro-systems/IGVFSM0387IPUP/",
"/in-vitro-systems/IGVFSM7869DXPV/"
],
"cas": "dCas9",
"cas_species": "Streptococcus pyogenes (Sp)",
"creation_timestamp": "2024-06-27T20:48:08.366265+00:00",
"documents": [
"/documents/d8ce793f-933b-45ea-9611-1c3f80cb7e11/"
],
"fused_domain": "KOX1-KRAB",
"lab": {
"@id": "/labs/jesse-engreitz/",
"title": "Jesse Engreitz, Stanford"
},
"modality": "interference",
"notes": "Fused_domain enum KRAB has been removed.",
"product_id": "addgene:85449",
"release_timestamp": "2024-02-07T19:03:01.113073+00:00",
"schema_version": "3",
"sources": [
"/labs/jesse-engreitz/"
],
"status": "released",
"submitted_by": {
"@id": "/users/43f2f757-5cbf-490a-9787-a1ee85a4cdcd/",
"title": "Jennifer Jou"
},
"submitter_comment": "This Crispr Modification is an identical replacement of the previously submitted Modification 2ba01755-df67-453b-b047-f7cdba236665. Doxycyline treatment was done only for the purpose of activating the domain",
"summary": "CRISPRi Sp-dCas9-KOX1-KRAB",
"uuid": "b4bc725a-8eeb-4180-9789-bece3516c0c1"
}