CRISPRa Sp-dCas9-VP64-p65-Rta (VPR)

{
    "@context": "/terms/",
    "@id": "/crispr-modifications/8b61bce4-105c-435e-9b32-1c8903566a9b/",
    "@type": [
        "CrisprModification",
        "Modification",
        "Item"
    ],
    "aliases": [
        "igvf:replacement_of_ec803a15-a3c1-4d14-b1be-be3a5ea1ef8a",
        "jay-shendure:dCas9-VPR-005"
    ],
    "audit": {},
    "award": {
        "@id": "/awards/HG011966/",
        "component": "functional characterization"
    },
    "biosamples_modified": [
        "/in-vitro-systems/IGVFSM9542NUGS/",
        "/in-vitro-systems/IGVFSM8338YZLA/",
        "/in-vitro-systems/IGVFSM1594ZOQH/"
    ],
    "cas": "dCas9",
    "cas_species": "Streptococcus pyogenes (Sp)",
    "creation_timestamp": "2024-06-27T20:48:11.800797+00:00",
    "description": "dCas9-VPR-005",
    "fused_domain": "VP64-p65-Rta (VPR)",
    "lab": {
        "@id": "/labs/jay-shendure/",
        "title": "Jay Shendure, UW"
    },
    "modality": "activation",
    "notes": "Fused_domain enum VPR has been renamed to be VP64-p65-Rta (VPR).",
    "release_timestamp": "2024-08-13T20:47:07.328992+00:00",
    "schema_version": "3",
    "sources": [
        "/sources/horizondiscovery/"
    ],
    "status": "released",
    "submitted_by": {
        "@id": "/users/43f2f757-5cbf-490a-9787-a1ee85a4cdcd/",
        "title": "Jennifer Jou"
    },
    "submitter_comment": "This Crispr Modification is an identical replacement of the previously submitted Modification ec803a15-a3c1-4d14-b1be-be3a5ea1ef8a.",
    "summary": "CRISPRa Sp-dCas9-VP64-p65-Rta (VPR)",
    "uuid": "8b61bce4-105c-435e-9b32-1c8903566a9b"
}