{
"@context": "/terms/",
"@id": "/construct-library-sets/IGVFDS7581DNXF/",
"@type": [
"ConstructLibrarySet",
"FileSet",
"Item"
],
"accession": "IGVFDS7581DNXF",
"aliases": [
"jay-shendure:construct_library_CRISPRa_Chardon-McDiarmid"
],
"applied_to_samples": [
{
"@id": "/in-vitro-systems/IGVFSM8382KOXO/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM8382KOXO",
"aliases": [
"jay-shendure:CRISPRa_VPH_NGN2_WTC11_neurons_10Xlane4"
],
"classifications": [
"differentiated cell specimen"
],
"donors": [
{
"@id": "/human-donors/IGVFDO1756PPKO/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0009747/",
"term_name": "GM25256 (WTC-11)"
}
],
"status": "released",
"summary": "GM25256 (WTC-11) differentiated cell specimen induced to neuron for 19 days (cellular sub pool: 10Xlane4), male, Homo sapiens modified with a guide library",
"targeted_sample_term": {
"@id": "/sample-terms/CL_0000540/",
"term_name": "neuron"
}
},
{
"@id": "/in-vitro-systems/IGVFSM1594ZOQH/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM1594ZOQH",
"aliases": [
"jay-shendure:CRISPRa_VPR_K562_10Xlane1"
],
"classifications": [
"cell line"
],
"donors": [
{
"@id": "/human-donors/IGVFDO9208RPQQ/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0002067/",
"term_name": "K562"
}
],
"status": "released",
"summary": "K562 cell line (cellular sub pool: 10Xlane1), female, Homo sapiens modified with a guide library"
},
{
"@id": "/in-vitro-systems/IGVFSM9003EMOQ/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM9003EMOQ",
"aliases": [
"jay-shendure:CRISPRa_VPH_NGN2_WTC11_neurons"
],
"classifications": [
"differentiated cell specimen"
],
"donors": [
{
"@id": "/human-donors/IGVFDO1756PPKO/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0009747/",
"term_name": "GM25256 (WTC-11)"
}
],
"status": "released",
"summary": "GM25256 (WTC-11) differentiated cell specimen induced to neuron for 19 days, male, Homo sapiens modified with a guide library",
"targeted_sample_term": {
"@id": "/sample-terms/CL_0000540/",
"term_name": "neuron"
}
},
{
"@id": "/in-vitro-systems/IGVFSM8338YZLA/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM8338YZLA",
"aliases": [
"jay-shendure:CRISPRa_VPR_K562"
],
"classifications": [
"cell line"
],
"donors": [
{
"@id": "/human-donors/IGVFDO9208RPQQ/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0002067/",
"term_name": "K562"
}
],
"status": "released",
"summary": "K562 cell line, female, Homo sapiens modified with a guide library"
},
{
"@id": "/in-vitro-systems/IGVFSM9913PXTT/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM9913PXTT",
"aliases": [
"jay-shendure:CRISPRa_VPH_NGN2_WTC11_neurons_10Xlane2"
],
"classifications": [
"differentiated cell specimen"
],
"donors": [
{
"@id": "/human-donors/IGVFDO1756PPKO/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0009747/",
"term_name": "GM25256 (WTC-11)"
}
],
"status": "released",
"summary": "GM25256 (WTC-11) differentiated cell specimen induced to neuron for 19 days (cellular sub pool: 10Xlane2), male, Homo sapiens modified with a guide library",
"targeted_sample_term": {
"@id": "/sample-terms/CL_0000540/",
"term_name": "neuron"
}
},
{
"@id": "/in-vitro-systems/IGVFSM8317ZTFV/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM8317ZTFV",
"aliases": [
"jay-shendure:CRISPRa_VPH_NGN2_WTC11_neurons_10Xlane3"
],
"classifications": [
"differentiated cell specimen"
],
"donors": [
{
"@id": "/human-donors/IGVFDO1756PPKO/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0009747/",
"term_name": "GM25256 (WTC-11)"
}
],
"status": "released",
"summary": "GM25256 (WTC-11) differentiated cell specimen induced to neuron for 19 days (cellular sub pool: 10Xlane3), male, Homo sapiens modified with a guide library",
"targeted_sample_term": {
"@id": "/sample-terms/CL_0000540/",
"term_name": "neuron"
}
},
{
"@id": "/in-vitro-systems/IGVFSM9778VZHD/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM9778VZHD",
"aliases": [
"jay-shendure:CRISPRa_VP64_K562"
],
"classifications": [
"cell line"
],
"donors": [
{
"@id": "/human-donors/IGVFDO9208RPQQ/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0002067/",
"term_name": "K562"
}
],
"status": "released",
"summary": "K562 cell line, female, Homo sapiens modified with a guide library"
},
{
"@id": "/in-vitro-systems/IGVFSM9390JSDH/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM9390JSDH",
"aliases": [
"jay-shendure:CRISPRa_VP64_K562_10Xlane2"
],
"classifications": [
"cell line"
],
"donors": [
{
"@id": "/human-donors/IGVFDO9208RPQQ/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0002067/",
"term_name": "K562"
}
],
"status": "released",
"summary": "K562 cell line (cellular sub pool: 10Xlane2), female, Homo sapiens modified with a guide library"
},
{
"@id": "/in-vitro-systems/IGVFSM9542NUGS/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM9542NUGS",
"aliases": [
"jay-shendure:CRISPRa_VPR_K562_10Xlane2"
],
"classifications": [
"cell line"
],
"donors": [
{
"@id": "/human-donors/IGVFDO9208RPQQ/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0002067/",
"term_name": "K562"
}
],
"status": "released",
"summary": "K562 cell line (cellular sub pool: 10Xlane2), female, Homo sapiens modified with a guide library"
},
{
"@id": "/in-vitro-systems/IGVFSM4521QSSO/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM4521QSSO",
"aliases": [
"jay-shendure:CRISPRa_VP64_K562_10Xlane1"
],
"classifications": [
"cell line"
],
"donors": [
{
"@id": "/human-donors/IGVFDO9208RPQQ/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0002067/",
"term_name": "K562"
}
],
"status": "released",
"summary": "K562 cell line (cellular sub pool: 10Xlane1), female, Homo sapiens modified with a guide library"
},
{
"@id": "/in-vitro-systems/IGVFSM7750SNNY/",
"@type": [
"InVitroSystem",
"Biosample",
"Sample",
"Item"
],
"accession": "IGVFSM7750SNNY",
"aliases": [
"jay-shendure:CRISPRa_VPH_NGN2_WTC11_neurons_10Xlane1"
],
"classifications": [
"differentiated cell specimen"
],
"donors": [
{
"@id": "/human-donors/IGVFDO1756PPKO/",
"taxa": "Homo sapiens"
}
],
"sample_terms": [
{
"@id": "/sample-terms/EFO_0009747/",
"term_name": "GM25256 (WTC-11)"
}
],
"status": "released",
"summary": "GM25256 (WTC-11) differentiated cell specimen induced to neuron for 19 days (cellular sub pool: 10Xlane1), male, Homo sapiens modified with a guide library",
"targeted_sample_term": {
"@id": "/sample-terms/CL_0000540/",
"term_name": "neuron"
}
}
],
"audit": {
"WARNING": [
{
"category": "missing files",
"detail": "Construct library set [IGVFDS7581DNXF](/construct-library-sets/IGVFDS7581DNXF/) has no `files`. File sets are expected to have files.",
"level": 40,
"level_name": "WARNING",
"name": "audit_no_files",
"path": "/construct-library-sets/IGVFDS7581DNXF/"
}
]
},
"award": {
"@id": "/awards/HG011966/",
"component": "functional characterization"
},
"control_for": [],
"creation_timestamp": "2024-01-31T00:00:44.930724+00:00",
"documents": [
"/documents/78f1cb67-1051-407c-9953-ba2c39ada2ae/",
"/documents/3d73a398-8fbb-4158-933e-d977b5768c0d/"
],
"file_set_type": "guide library",
"files": [],
"guide_type": "sgRNA",
"input_file_set_for": [],
"integrated_content_files": [
{
"@id": "/tabular-files/IGVFFI0163YAMA/",
"accession": "IGVFFI0163YAMA",
"aliases": [
"jay-shendure:tabularfile_CRISPRa_guidefile_Chardon-McDiarmid"
],
"content_type": "guide RNA sequences",
"file_format": "csv",
"upload_status": "validated"
}
],
"lab": {
"@id": "/labs/jay-shendure/",
"title": "Jay Shendure, UW"
},
"large_scale_loci_list": {
"@id": "/tabular-files/IGVFFI0163YAMA/",
"accession": "IGVFFI0163YAMA",
"aliases": [
"jay-shendure:tabularfile_CRISPRa_guidefile_Chardon-McDiarmid"
]
},
"publications": [
{
"@id": "/publications/20fcbdbb-5a47-41c6-b80b-e6dd0e8a8d3e/",
"publication_identifiers": [
"doi:10.1101/2023.03.28.534017"
]
}
],
"release_timestamp": "2024-08-13T20:47:07.265644+00:00",
"schema_version": "9",
"scope": "loci",
"selection_criteria": [
"TF binding sites",
"candidate cis-regulatory elements"
],
"status": "released",
"submitted_by": {
"@id": "/users/73f58e9f-8f5d-4fee-a7cd-dd63c0167e4b/",
"title": "Beth Martin"
},
"summary": "Guide (sgRNA) library targeting TF binding sites, candidate cis-regulatory elements in many genomic loci",
"uuid": "1043a27b-01ca-4314-8312-be6ab2fa35c4"
}